Prognostic Alternative Splicing Signatures in Esophageal Carcinoma.

Cancer Management and Research
Zodwa DlaminiAristotelis Chatziioannou

Abstract

Alternative splicing (AS) is a method of increasing the number of proteins that the genome is capable of coding for, by altering the pre-mRNA during its maturation. This process provides the ability of a broad range of proteins to arise from a single gene. AS events are known to occur in up to 94% of human genes. Cumulative data have shown that aberrant AS functionality is a major factor in human diseases. This review focuses on the contribution made by aberrant AS functionality in the development and progression of esophageal cancer. The changes in the pattern of expression of alternately spliced isoforms in esophageal cancer can be used as diagnostic or prognostic biomarkers. Additionally, these can be used as targets for the development of new treatments for esophageal cancer.

References

Jul 1, 1993·The Journal of Cell Biology·R J PeachA Aruffo
Aug 15, 1996·The Biochemical Journal·D R Flower
Oct 11, 1996·The Journal of Biological Chemistry·M J BessmanS F O'Handley
May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·R KneeP R Murphy
Apr 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J W Shay, S Bacchetti
Nov 22, 1997·Current Opinion in Immunology·B J Van den Eynde, P van der Bruggen
Jun 24, 1998·Genes & Development·J WangG J Hannon
Sep 4, 1998·Science·T C HeK W Kinzler
Dec 5, 1998·The Journal of Biological Chemistry·H LiJ P Liu
Mar 13, 1999·International Journal of Cancer. Journal International Du Cancer·S KyoM Inoue
May 18, 1999·The American Journal of Pathology·C A RumpelC A Moskaluk
Jul 15, 1999·International Journal of Cancer. Journal International Du Cancer·T W ParkF Jänicke
Aug 14, 1999·International Journal of Cancer. Journal International Du Cancer·D RimoldiJ C Cerottini
Sep 10, 1999·Journal of Cancer Research and Clinical Oncology·C BachorP Boukamp
Feb 16, 2000·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·R V LordP V Danenberg
Jul 27, 2000·Annals of the New York Academy of Sciences·J Behrens
Aug 30, 2000·Proceedings of the National Academy of Sciences of the United States of America·Z RekasiG Halmos
Oct 6, 2000·Endocrine-related Cancer·C J PowersA Wellstein
Nov 4, 2000·Biochimica Et Biophysica Acta·D R FlowerC E Sansom
Nov 4, 2000·Biochimica Et Biophysica Acta·D R Flower
Feb 24, 2001·Neoplasia : an International Journal for Oncology Research·L M ColginR R Reddel
Feb 24, 2001·Neoplasia : an International Journal for Oncology Research·X YiJ W Shay
Mar 30, 2001·European Journal of Biochemistry·H TschescheS Bartsch
Apr 17, 2001·Experimental Cell Research·K Ohman Forslund, K Nordqvist

❮ Previous
Next ❯

Software Mentioned

BLAST
NGALR
Mixture of Isoforms ( MISO )

Related Concepts

Related Feeds

Alternative splicing

Alternative splicing a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Here is that latest research.