Prognostic Analysis of 102 Patients with Synchronous Colorectal Cancer and Liver Metastases Treated with Simultaneous Resection

Chinese Medical Journal
Yefan ZhangJianqiang Cai

Abstract

The liver is the most common site for colorectal cancer (CRC) metastases. Their removal is a critical and challenging aspect of CRC treatment. We investigated the prognosis and risk factors of patients with CRC and liver metastases (CRCLM) who underwent simultaneous resections for both lesions. From January 2009 to August 2016, 102 patients with CRCLM received simultaneous resections of CRCLM at our hospital. We retrospectively analyzed their clinical data and analyzed their outcomes. Overall survival (OS) and disease-free survival (DFS) were examined by Kaplan-Meier and log-rank methods. Median follow-up time was 22.7 months; no perioperative death or serious complications were observed. Median OS was 55.5 months; postoperative OS rates were 1-year: 93.8%, 3-year: 60.7%, and 5-year: 46.4%. Median DFS was 9.0 months; postoperative DFS rates were 1-year: 43.1%, 3-year: 23.0%, and 5-year 21.1%. Independent risk factors found in multivariate analysis included carcinoembryonic antigen ≥100 ng/ml, no adjuvant chemotherapy, tumor thrombus in liver metastases, and bilobar liver metastases for OS; age ≥60 years, no adjuvant chemotherapy, multiple metastases, and largest diameter ≥3 cm for DFS. Simultaneous surgical resection is a safe ...Continue Reading

References

May 17, 2006·Archives of Surgery·Thomas A AloiaEddie K Abdalla
Aug 15, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Eric Van CutsemUNKNOWN European Colorectal Metastases Treatment Group
Dec 26, 2009·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S J MougP G Horgan
Jan 10, 2012·World Journal of Gastrointestinal Surgery·Reinhart T Grundmann
Jan 15, 2015·Cancer Cell·Christina PfirschkeMikael J Pittet
Nov 24, 2016·Chinese Journal of Cancer Research = Chung-kuo Yen Cheng Yen Chiu·Yuan LiJianqiang Cai

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