Prognostic and biologic significance of chromosomal imbalances assessed by comparative genomic hybridization in multiple myeloma.

Blood
Norma C GutiérrezJ F San Miguel

Abstract

Cytogenetic abnormalities, evaluated either by karyotype or by fluorescence in situ hybridization (FISH), are considered the most important prognostic factor in multiple myeloma (MM). However, there is no information about the prognostic impact of genomic changes detected by comparative genomic hybridization (CGH). We have analyzed the frequency and prognostic impact of genetic changes as detected by CGH and evaluated the relationship between these chromosomal imbalances and IGH translocation, analyzed by FISH, in 74 patients with newly diagnosed MM. Genomic changes were identified in 51 (69%) of the 74 MM patients. The most recurrent abnormalities among the cases with genomic changes were gains on chromosome regions 1q (45%), 5q (24%), 9q (24%), 11q (22%), 15q (22%), 3q (16%), and 7q (14%), while losses mainly involved chromosomes 13 (39%), 16q (18%), 6q (10%), and 8p (10%). Remarkably, the 6 patients with gains on 11q had IGH translocations. Multivariate analysis selected chromosomal losses, 11q gains, age, and type of treatment (conventional chemotherapy vs autologous transplantation) as independent parameters for predicting survival. Genomic losses retained the prognostic value irrespective of treatment approach. According ...Continue Reading

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Citations

Nov 3, 2007·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·N C GutiérrezJ F San Miguel
Dec 17, 2009·The Cancer Journal·Jesus San-MiguelNorma C Gutierrez
Oct 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Paola E LeoneGareth J Morgan
May 27, 2006·Blood·Fenghuang ZhanJohn D Shaughnessy
Aug 19, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hervé Avet-LoiseauStéphane Minvielle
Dec 23, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joan BladéRobert A Kyle
Apr 3, 2014·Molecular Cytogenetics·Pau Ni Ivyna BongZubaidah Zakaria
Jun 29, 2014·Blood Cells, Molecules & Diseases·Flavia StellaIrma Slavutsky
Feb 16, 2012·Leukemia·B PaivaUNKNOWN GEM (Grupo Español de Mieloma)/PETHEMA (Programa para el Estudio de la Terapéutica en Hemopatías Malignas) cooperative
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Aug 24, 2005·British Journal of Haematology·Laura RosiñolEmili Montserrat
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