Prognostic and clinicopathological significance of CXCL1 in cancers: a systematic review and meta-analysis

Cancer Biology & Therapy
Zulei ZhangYakun Zhan

Abstract

Background The prognostic value of Chemokine (C-X-C motif) ligand 1 (CXCL1) in various types of cancer remains controversial. Here we aimed to evaluate the prognostic role of CXCL1 for cancer. Methods A comprehensively search of the PubMed, Embase, Web of Science, Wanfang and China National Knowledge Internet databases was conducted to retrieve eligible studies meeting the inclusion criteria. Overall survival (OS), progression-free survival (PFS) and various clinicopathological parameters were defined as endpoints. Stata SE12.0 software was used for quantitative meta-analysis. Results A total of 17 studies encompassing 2265 cancer patients were included. Our meta-analysis showed that patients with higher CXCL1 expression had significantly shorter OS, according to both multivariate (HR 1.51, 95% CI 1.19-1.83, P < .01) and univariate analysis (HR 2.08, 95% CI 1.62-2.54, P < .01). Furthermore, higher CXCL1 expression was significantly correlated with advanced TNM stage and lymph node metastasis (both P < .05). Conclusions High CXCL1 expression is a risk factor for cancer prognosis indicating a poor OS, and advanced TNM stage and lymph node metastasis, demonstrating that it may be a promising prognostic biomarker for different canc...Continue Reading

References

Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S HaskillR Sager
Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·A AnisowiczR Sager
Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·I Clark-LewisM Baggiolini
Nov 30, 2007·Endocrine-related Cancer·Ivan BiècheGwendal Lazennec
Feb 24, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·W-L ChengK-H Lin
Mar 10, 2011·International Journal of Cancer. Journal International Du Cancer·Jianbo XuWenhua Zhan
Oct 13, 2011·The Journal of Pathology·Frances R Balkwill
Sep 26, 2015·Cancer Biomarkers : Section a of Disease Markers·Masakazu NakashimaOsamu Ogawa
Jun 3, 2016·CA: a Cancer Journal for Clinicians·Kimberly D MillerAhmedin Jemal
Jan 6, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal

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