Prognostic and clinicopathological value of MUC1 expression in colorectal cancer: A meta-analysis

Medicine
Chao LiLei Wang

Abstract

Accumulating evidence supports the overexpression of mucin 1 (MUC1) in colorectal cancer (CRC), but the value of elevated MUC1 expression remains controversial. Here, we evaluated the prognostic and clinicopathological value of MUC1 expression in CRC. The Web of Science, PubMed, Embase, Cochrane Library, and Wanfang databases, as well as the China Biology Medicine disc (CBMdisc) and China National Knowledge Infrastructure (CNKI) were searched for studies on MUC1 expression and prognosis of CRC through July 20, 2018. The pooled relative risks (RRs) and hazard ratios (HRs) with 95% confidence intervals (95% CIs) were calculated to evaluate the prognostic and clinicopathological value of MUC1 expression in CRC. The Revman version 5.3 package and STATA, version 12 were employed for pooled analysis and analysis of publication bias. This meta-analysis included 16 published studies. The combined analysis showed that CRC patients with high MUC1 expression had a worse clinical outcome in overall survival (OS) (HR = 1.51, 95% CI = 1.30-1.75, P <.00001). In addition, high MUC1 expression was associated with higher TNM stage (RR = 1.44, 95% CI = 1.17-1.77, P = .0007), greater depth of invasion (RR = 1.30, 95% CI = 1.10-1.53, P = .002), and...Continue Reading

References

Feb 7, 1998·Journal of Hepatology·B VandenhauteJ P Aubert
Apr 18, 2000·Japanese Journal of Clinical Oncology·K MatsudaY Ajioka
Feb 15, 2001·Digestion·T HayashiK Imai
Feb 19, 2002·Journal of Korean Medical Science·Kee Taek JangHyung Sik Shin
Jul 29, 2003·Journal of Surgical Oncology·Jaw-Yuan WangShiu-Ru Lin
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Dec 19, 2003·Nature Reviews. Cancer·Michael A Hollingsworth, Benjamin J Swanson
Apr 23, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Stephan E BaldusHans P Dienes
Nov 20, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J S de BonoA W Tolcher
Jul 12, 2005·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Uwe KarstenSteffen Goletz
Feb 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·René H VerheijenMichael V Seiden
Feb 14, 2006·Clinical & Experimental Metastasis·Paul J CozziYong Li
Feb 21, 2006·Biochimica Et Biophysica Acta·Mahefatiana AndrianifahananaSurinder K Batra
Jul 19, 2006·Breast Cancer Research : BCR·Christine L Hattrup, Sandra J Gendler
Jul 22, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jeng-Fu YouReiping Tang
Mar 14, 2007·World Journal of Surgical Oncology·Timothy J DuncanLindy G Durrant
Apr 6, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Shinjiro NagaiFumihiro Tanaka
Jul 28, 2007·World Journal of Gastroenterology : WJG·Iwao KanekoKazuaki Chayama
Sep 14, 2007·Annual Review of Physiology·Christine L Hattrup, Sandra J Gendler
Oct 24, 2007·Human Pathology·Matthias WoenckhausWolfgang Dietmaier
Nov 17, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Carolyn C Compton
May 7, 2008·International Journal of Colorectal Disease·Rodrigo Oliva PerezAngelita Habr-Gama
Jul 6, 2010·The Journal of Obstetrics and Gynaecology Research·Shinichi TogamiTsutomu Douchi
Dec 1, 2010·Medical Oncology·Dongrong SituTiehua Rong
Sep 1, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nuhad K IbrahimMark Pegram
Mar 21, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hideki UenoKenichi Sugihara
Aug 8, 2012·Proceedings of the National Academy of Sciences of the United States of America·Nina V ChaikaPankaj K Singh

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