Prognostic and clinicopathological value of PBRM1 expression in renal cell carcinoma

Clinica Chimica Acta; International Journal of Clinical Chemistry
Zhun WangYuanjien Niu

Abstract

The prognostic value of PBRM1 expression in renal cell carcinoma (RCC) had been investigated in previous studies; however, the results remain inconclusive. We investigated the prognostic value and clinicopathological significance of PBRM1 protein expression in RCC. PubMed, Embase, Web of Science, and Cochrane database were searched for studies investigating the relationships between PBRM1 expression and outcomes in RCC. Hazard ratios (HRs) for survival outcomes and odds ratios (ORs) for clinical parameters were extracted from eligible studies. Heterogeneity was assessed using the I2 value. The fixed-effects model was used if there was no evidence of heterogeneity; otherwise, the random-effects model was used. Publication bias was evaluated using Begg's funnel plots and Egger's regression test. A total of 2942 patients from 7 studies were included in the meta-analysis. The results showed that decreased expression of PBRM1 is associated with poor overall survival (OS) (HR = 2.11, 95% CI: 1.52-2.96), cancer-specific survival (CSS) (HR = 1.32, 95% CI: 1.10-1.58), and progression-free survival/ recurrence-free survival (PFS/RFS) (HR = 1.57, 95%CI: 1.34-1.85) in RCC. In addition, PBRM1 positive expression was significantly associated...Continue Reading

Citations

Nov 20, 2019·International Journal of Molecular Sciences·Fuyan HuXiaoping Liu
Dec 22, 2019·Cancers·Lucía Carril-AjuriaGuillermo de Velasco
Oct 2, 2020·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Venkata S KatabathinaSrinivasa R Prasad
Jan 5, 2020·Insights Into Imaging·Roberto Lo GulloKatja Pinker
Jan 21, 2022·European Radiology·Yana QiMingyong Han

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