Prognostic and Clinicopathological Value of Programmed Cell Death Ligand1 Expression in Patients With Small Cell Lung Cancer: A Meta-Analysis

Frontiers in Oncology
Huarong CaiYuequan Jiang

Abstract

Background: Programmed death-ligand 1 (PD-L1) is an immune checkpoint molecule expressed by cancer cells. Previous studies have demonstrated the prognostic role of PD-L1 expression in patients with small cell lung cancer (SCLC), where the results were inconsistent. Therefore, we conducted a meta-analysis to identify the prognostic impact of PD-L1 on SCLC. Methods: We searched the PubMed, Embase, ISI Web of Science, and Cochrane Library databases for articles published before and on March 2nd, 2020. Data of PD-L1 expression in tumor cells detected using immunohistochemistry methods were extracted for analysis. Pooled hazard ratios (HRs) with confidence intervals (CIs) and odds ratios (ORs) with 95% CIs were calculated to assess the correlations among PD-L1, overall survival (OS), and clinicopathological factors. Results: Nine studies of 921 patients published between 2015 and 2019 were included in this meta-analysis. The pooled data (HR = 0.91, 95% CI = 0.46-1.80, p = 0.787) indicated that PD-L1 expression is not a significant predictor of poor OS. Moreover, the results also revealed that PD-L1 expression is not significantly associated with gender (OR = 1.12, 95% CI = 0.73-1.74, p = 0.601), age (OR = 1.15, 95% CI = 0.58-2.30, p...Continue Reading

References

Sep 1, 1986·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K OsterlindP K Andersen
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Sep 30, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ramaswamy GovindanJay Piccirillo
Jul 23, 2009·BMJ : British Medical Journal·David MoherUNKNOWN PRISMA Group
Nov 11, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Hidenobu IshiiTomoaki Hoshino
Oct 13, 2016·Seminars in Respiratory and Critical Care Medicine·Gregory P Kalemkerian
Jan 13, 2017·The Breast Journal·Changjun WangQiang Sun
Aug 17, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Patrick A OttJanice M Mehnert
Mar 27, 2018·Hepatobiliary & Pancreatic Diseases International : HBPD INT·He-Li GaoXian-Jun Yu
Aug 5, 2018·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·L BonannoP F Conte
Sep 12, 2018·BMJ : British Medical Journal·Xian Shen, Bin Zhao
Oct 4, 2018·The New England Journal of Medicine·Leora HornUNKNOWN IMpower133 Study Group
Oct 14, 2018·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Neal ReadyScott J Antonia
Jan 9, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Martin ReckJulie R Brahmer
Jan 22, 2019·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Jean-Louis PujolPierre-Jean Souquet
Jan 25, 2019·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Martin ReckRamaswamy Govindan
Feb 9, 2019·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Xiaoliang ZhaoGiuseppe Giaccone
Feb 12, 2019·Experimental Hematology & Oncology·Vaibhav VermaAbhijai Singh
Feb 13, 2019·Japanese Journal of Clinical Oncology·Keita NakanishiYukinori Sakao
Apr 28, 2019·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Mickaël Lattuca-TrucUNKNOWN Multidisciplinary Thoracic Oncology Group Grenoble University Hospital France
May 3, 2019·Journal of Hematology & Oncology·Sen YangQiming Wang
May 31, 2019·Cancer Cell International·Xiaobin GuYonggang Shi
Jul 30, 2019·OncoTargets and Therapy·Orgilmaa RegzedmaaJun Chen
Oct 21, 2019·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Neal E ReadyDavid R Spigel

❮ Previous
Next ❯

Citations

Dec 8, 2020·Frontiers in Oncology·Sonam PuriJhanelle E Gray

❮ Previous
Next ❯

Software Mentioned

Stata

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.