Prognostic and predictive factors in patients with brain metastases from solid tumors: A review of published nomograms

Critical Reviews in Oncology/hematology
Carsten NiederAnca L Grosu

Abstract

To review published nomograms that predict endpoints such as overall survival (OS) or risk of intracranial relapse in patients with brain metastases from solid tumors. The methods and results of nomogram studies identified by a systematic search were extracted and compared, stratified by endpoint predicted by the respective nomograms. In particular, validation strategies (external/internal), concordance indices (cut-off 0.75) and comparisons to older models were analyzed. Six publications reported on prediction of OS. Most of these analyses focused on one particular primary tumor site, e.g., breast cancer or hepatocellular carcinoma, while the largest study included different primary tumor sites. The median number of patients was 244. Three of six studies included external validation cohorts. With few exceptions, concordance indices <0.75 were reported. In all studies reporting this endpoint, the nomogram outperformed older prognostic scores. Two nomograms focused on development of new brain metastases after radiosurgery (one externally validated), one on survival free from salvage whole brain radiotherapy (WBRT) after radiosurgery, and one on neurologic and non-neurologic death in patients receiving radiosurgery after WBRT fai...Continue Reading

Citations

Jul 30, 2019·Critical Reviews in Oncology/hematology·Jonathan W RickManish K Aghi
Dec 23, 2020·American Journal of Clinical Oncology·Carsten NiederBård Mannsåker
Jan 20, 2021·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·K Holub, G Louvel
Mar 7, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Carsten NiederDirk De Ruysscher
May 15, 2021·Journal of Cellular and Molecular Medicine·Liwei WuLin Wang
Jan 22, 2021·Oncology Research and Treatment·Carsten NiederEllinor Haukland
Sep 9, 2020·The International Journal of Biochemistry & Cell Biology·Bingjie ZengDong Li
Jan 13, 2022·Journal of Cancer Research and Clinical Oncology·Carsten NiederEllinor Haukland

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