Prognostic and predictive value of plasma D-dimer levels in patients with small-cell lung cancer

International Journal of Clinical Oncology
Cuicui ZhangKai Li

Abstract

To investigate the predictive value of plasma D-dimer levels for short-term therapeutic effect and progression-free survival (PFS) in patients with small-cell lung cancer (SCLC); and to analyze the correlation between baseline plasma D-dimer levels and other clinicopathological features. The aim of the study was to investigate whether the levels of plasma D-dimer could serve as a predictive and prognostic factor in patients with SCLC. A retrospective review of the clinicopathological data of 160 patients with pathologically confirmed SCLC, who were treated at the Department of Thoracic Oncology of Tianjin Medical University Tumor Institute and Hospital between June 2011 and June 2016, was performed. At the same time, we collected 100 patients with benign pulmonary diseases as a control group. The correlations between baseline plasma D-dimer levels and other clinical features, therapeutic effect and PFS were analyzed statistically. The level of plasma D-dimer in patients with SCLC was significantly higher than that of patients with benign pulmonary diseases (P = 0.001). The PFS of patients with elevated D-dimer levels before therapy were significantly shorter than that of patients with normal D-dimer levels (6.0 versus 7.5 month...Continue Reading

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Citations

Mar 21, 2019·Medical Oncology·Michał ZąbczykAnetta Undas
Jun 1, 2020·World Journal of Surgical Oncology·Zhoujunyi TianGuangliang Qiang
Oct 25, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Dariusz GrzeleckiMarcin Tyrakowski
Feb 11, 2021·Technology in Cancer Research & Treatment·Jialong LiGuowei Che

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