Prognostic and Therapeutic Implications of Microvascular Invasion in Hepatocellular Carcinoma

Annals of Surgical Oncology
Derek J Erstad, Kenneth K Tanabe

Abstract

Hepatocellular carcinoma (HCC) is a morbid condition for which surgical and ablative therapy are the only options for cure. Nonetheless, over half of patients treated with an R0 resection will develop recurrence. Early recurrences within 2 years after resection are thought to be due to the presence of residual microscopic disease, while late recurrences > 2 years after resection are thought to be de novo metachronous HCCs arising in chronically injured liver tissue. Microvascular invasion (MVI) is defined as the presence of micrometastatic HCC emboli within the vessels of the liver, and is a critical determinant of early recurrence and survival. In this review, we summarize the pathogenesis and clinical relevance of MVI, which correlates with adverse biological features, including high grade, large tumor size, and epithelial-mesenchymal transition. Multiple classification schemas have been proposed to capture the heterogeneous features of MVI that are associated with prognosis. However, currently, MVI can only be determined based on surgical specimens, limiting its clinical applicability. Going forward, advances in axial imaging technologies, molecular characterization of biopsy tissue, and novel serum biomarkers hold promise a...Continue Reading

References

May 9, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S JonasP Neuhaus
Jan 5, 2002·The American Journal of Surgical Pathology·Gregory Y LauwersUNKNOWN International Cooperative Study Group on Hepatocellular Carcinoma
Dec 12, 2003·Lancet·Josep M LlovetJordi Bruix
Feb 10, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jin Woo KimXin Wei Wang
May 27, 2005·Seminars in Liver Disease·Josep M LlovetVincenzo Mazzaferro
Aug 27, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Timothy M PawlikEddie K Abdalla
Sep 19, 2006·Transplantation Proceedings·K W LeeJ W Joh
Mar 31, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Jeremy R ParfittDavid K Driman
May 23, 2007·Nature Biotechnology·Eran SegalMichael D Kuo
Feb 29, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Soo Hyung RyuKyu-Won Kim
Mar 6, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Emilia FransveaGianluigi Giannelli
May 18, 2011·Annals of Surgical Oncology·Yan-Ming ZhouJia-Mei Yang
Jun 10, 2011·The British Journal of Surgery·S T FanS C Chan
Jun 28, 2011·Journal of Hepatology·Beatriz MínguezJosep M Llovet
Oct 14, 2011·International Journal of Hepatology·Gitonga MuneneElijah Dixon
Dec 29, 2011·Annals of Surgical Oncology·Yo-ichi YamashitaYoshihiko Maehara
May 12, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sasan RoayaieVincenzo Mazzaferro
Sep 22, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yan YanHua Tang
Nov 15, 2012·Annals of Surgical Oncology·Manuel Rodríguez-PerálvarezAndrew Kenneth Burroughs
Dec 12, 2012·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Hung-Hsu HungJaw-Ching Wu

❮ Previous
Next ❯

Citations

May 22, 2019·Annals of Surgical Oncology·Derek J Erstad, Kenneth K Tanabe
Jan 23, 2020·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Simone FamularoFabrizio Romano
Dec 29, 2020·Hepatology International·Xia ShengUNKNOWN Liver Cancer Pathology Group of China (LCPGC)
Dec 3, 2020·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Tomoaki YohKojiro Taura
Nov 17, 2020·Frontiers in Medicine·Qi ZhangTingbo Liang
Oct 23, 2020·World Journal of Gastroenterology : WJG·Miguel Jiménez Pérez, Rocío González Grande
Apr 2, 2021·The British Journal of Surgery·T TakayamaUNKNOWN Liver Cancer Study Group of Japan
Apr 7, 2021·Updates in Surgery·Roberto SantambrogioMarco Antonio Zappa
May 11, 2021·World Journal of Gastroenterology : WJG·Jia-Sheng CaoXiu-Jun Cai
Jun 15, 2021·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Xuqi SunMing Zhao
May 1, 2021·Clinics and Research in Hepatology and Gastroenterology·Minghao YangXiao Cui
Oct 11, 2021·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Shu-Cheng LiuWei-Ching Lin
Apr 2, 2020·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Gregory C WilsonAllan Tsung
Dec 7, 2021·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Wong Hoi SheTan To Cheung

❮ Previous
Next ❯

Related Concepts