PMID: 22338460Jul 1, 2010Paper

Prognostic and therapeutic role of nuclear factor-kappa B (NF-kappaB) in breast cancer

Journal of Ayub Medical College, Abbottabad : JAMC
Ayesha Ahmed

Abstract

Nuclear Factor- kappa B (NF-kappaB) is an essential transcription factor that not only modulates cellular responses to stress but also plays a pivotal role in inflammation, immunity, cell cycle growth and survival. NF-kappaB-regulated genes have been documented to be involved in cellular proliferation and invasion along with tumour related angiogenesis and lymphangiogenesis. Dysregulation of NF-kappaB associated pathways are seen in multiple malignancies. Its constitutive activation in the clinically aggressive and prognostically poor ER-negative, Her2-neu positive and inflammatory breast cancer could formulate the basis for its evolution as a potential prognostic and therapeutic target.

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