PMID: 9531362Apr 8, 1998Paper

Prognostic biomarker study in pathologically staged N1 non-small cell lung cancer

International Journal of Radiation Oncology, Biology, Physics
R KomakiN G Ordonez

Abstract

The prognostic influence of 6 biomarkers correlated to histologic subtypes of non-small cell lung cancer (NSCLC) on loco-regional control, overall survival, disease-free survival (DFS), and distant disease control (DDC) rates, all measured at 5 years, were examined. Cell blocks from the primary tumors of 137 patients with pathologically staged N1 NSCLC at MDACC were analyzed by 6-biomarker status correlated to histological subtypes and their outcomes. The ranges of biomarker values were as follows: apoptotic index, 0.2-2.8%; mitotic index, 0-1.8%; the proportion of cells in S+G2M, 3-36%; p53 status, 0-100%; Ki-67, 0-9.3%; DNA index, 1.0-2.74. Subtypes of 137 cases from the postoperative pathology specimen showed that 74 patients had squamous carcinoma and 63 patients had adenocarcinoma. Mean and median lengths of follow-up were 4.21 years and 2.43 years, respectively. Patients with squamous cell carcinoma (SCC) had a better 5-year survival (p = 0.006), DFS (p = 0.002), and distant metastasis control (p = 0.002) than patients with adenocarcinoma (AC). Among patients with AC, the DNA index was a significant predictor of 5-year DFS (p = 0.02), DDC rate (p = 0.04), and local-regional control (p < 0.05). Higher apoptosis (p = 0.03) ...Continue Reading

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Citations

Oct 26, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Johannes M A DanielsJohan C van Mourik
Jul 20, 2002·International Journal of Radiation Oncology, Biology, Physics·Robbin S BubbLuka Milas
Mar 21, 2002·Histopathology·D C Brown, K C Gatter
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Sep 2, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Hubert VesselleDouglas E Wood
Jun 23, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Yoichi AnamiMasayuki Noguchi
Jul 19, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Anna GasinskaSonia Dyczek
Sep 13, 2002·Chest·Michael D BrundageWilliam J Mackillop
Oct 21, 2003·International Journal of Cancer. Journal International Du Cancer·Marina PollánJose María Rojas
Mar 5, 2003·Pharmacological Reviews·Romano DanesiMario Del Tacca
Feb 24, 2001·Annals of the New York Academy of Sciences·B JosephB Zhivotovsky

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