Prognostic biomarkers in men with metastatic castration-resistant prostate cancer receiving [177Lu]-PSMA-617.

European Journal of Nuclear Medicine and Molecular Imaging
Justin FerdinandusMichael S Hofman

Abstract

We analysed quantitative biomarkers derived from both baseline whole-body imaging and blood serum to identify prognostic markers in patients treated within the lutetium-177 prostate-specific membrane antigen (LuPSMA) phase 2 trial. PET image analysis was carried out using whole-body segmentation quantifying molecular tumour volume (SUV > 3 threshold for PSMA, SUV > liver+2sd for fluorodeoxyglucose (FDG) including SUVmax and SUVmean. For baseline bone scans, EXINI bone scan index (BSI) was used to calculate the percentage of involved bone. Baseline alkaline phosphatase (ALP), lactate dehydrogenase (LDH), prostate specific antigen (PSA) and PSA doubling time were also used in this analysis. We used univariate cox regression analysis and log-rank comparison with optimised cut-offs to find suitable biomarkers prognostic of overall survival from time of enrolment. This analysis identified FDG-positive tumour volume (FDGvol; HR 2.6; 95% CI, 1.4-4.8), mean intensity of PSMA-avid tumour uptake (PSMAmean; HR 0.89; 95% CI, 0.8-0.98), bone scan index (BSI; HR 2.3; 95% CI, 1.2-4.4), ALP (HR 1.1; 95% CI, 1-1.2) and LDH (HR 1.2; 95% CI, 1-1.5) as biomarkers prognostic of overall survival. In addition to established biomarkers, both FDG and P...Continue Reading

References

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Oct 7, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·John VioletMichael S Hofman

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Citations

Jul 4, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Stefano FantiAnders Bjartell
Jun 13, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Beihe WangYao Zhu
Apr 8, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Aravind S Ravi Kumar, Michael S Hofman
Jan 24, 2021·European Urology Focus·Manuel WeberClaudia Kesch
Jan 14, 2021·European Urology·Nattakorn DhiantravanAravind S Ravi Kumar
Dec 10, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sinan WangJiang He
Mar 9, 2021·Frontiers in Oncology·Panagiotis J VlachostergiosScott T Tagawa
Apr 1, 2021·Radiology·Courtney Lawhn-HeathThomas A Hope
May 26, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Hojjat AhmadzadehfarKambiz Rahbar
Jun 1, 2021·PET Clinics·Robert SeifertKambiz Rahbar
Jul 3, 2021·Diagnostics·Panagiotis J VlachostergiosVassilios Tzortzis
Jul 25, 2021·International Journal of Molecular Sciences·Magdalena StaniszewskaJanette Iking
Aug 8, 2021·Cancers·Kgomotso MokoalaMike Sathekge
Aug 9, 2021·Lancet·Michael S HofmanLouise Emmett
Aug 15, 2021·European Journal of Radiology·Justin FerdinandusStefano Fanti
Oct 9, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Steffie M B PetersWalter Jentzen
Nov 3, 2021·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Jeremie Calais, Johannes Czernin

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