Prognostic comparison between number and distribution of lymph node metastases in patients with right-sided colon cancer

Annals of Surgical Oncology
Chang Hyun KimYoung Jin Kim

Abstract

Lymph node metastasis is the most important prognostic indicator for colon cancer patients. We compared the prognostic significance of the number of lymph node metastases (LNN) and the distribution of lymph node metastases (LND). A total of 187 patients underwent curative resection for stage III right-sided colon cancer between 2000 and 2010. We evaluated the oncologic outcomes according to LNN (N1 1-3, N2 4-6, N3 >6) and LND (LND1 metastases in pericolic nodes, LND2 metastases along the major vessels, N3 metastases around the origin of a main artery). A Cox proportional hazards model, with backward stepwise analysis was used to determine the effects of covariates on 5-year, disease-free survival (DFS) and 5-year overall survival (OS). Akaike's information criterion (AIC), and Harrell's concordance index (C-index) were compared for each developed model. During the median follow-up of 42.2 months, 5-year DFS and OS were 68 and 79.3 %, respectively. Multivariate analysis showed that both LNN and LND3 were independent prognostic factor for both 5-year DFS and OS. However, the prognostic model incorporating number of LNM was more precise than that of LND, with a lower AIC (5-year DFS, 554.2 vs. 566.9; 5-year OS, 318.1 vs. 337.9) an...Continue Reading

References

Jan 1, 1992·The Prostate. Supplement·F H SchröderM Pavone-Macaluso
Jul 1, 1993·Diseases of the Colon and Rectum·B MalassagneP Hautefeuille
Aug 1, 1996·Diseases of the Colon and Rectum·A Garćia-RuizP Marchesa
Apr 20, 2001·Journal of the National Cancer Institute·H NelsonUNKNOWN National Cancer Institute Expert Panel
Nov 15, 2001·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·UNKNOWN Japanese Gastric Cancer Association
Jun 13, 2003·Surgical and Radiologic Anatomy : SRA·T ShatariS Kodaira
Sep 1, 1958·British Journal of Cancer·C E DUKES, H J BUSSEY
Jan 14, 2004·Diseases of the Colon and Rectum·Carlos A VaccaroJose M Lastiri
Jul 26, 2005·Journal of the American College of Surgeons·Jin-ichi HidaHitoshi Shiozaki
Mar 26, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tobias LeiboldJosé G Guillem
Sep 11, 2008·Journal of the National Cancer Institute·Karl Y BilimoriaClifford Y Ko
Dec 2, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nicholas P WestPhilip Quirke
Dec 2, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Leonard L GundersonAndrew K Stewart
Dec 17, 2009·Diseases of the Colon and Rectum·Frank BenedixUNKNOWN Colon/Rectum Carcinomas (Primary Tumor) Study Group
Mar 20, 2010·Annals of Surgical Oncology·Jung Wook HuhHyeong Rok Kim
Oct 18, 2011·International Journal of Clinical Oncology·Toshiaki WatanabeUNKNOWN Japanese Society for Cancer of the Colon and Rectum
Apr 5, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nicholas P WestPhilip Quirke
Dec 18, 2012·World Journal of Surgery·Niamh M Hogan, Desmond C Winter
Jun 7, 2013·Diseases of the Colon and Rectum·Yukihide KanemitsuTomoyuki Kato

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Citations

Aug 26, 2015·World Journal of Surgery·Toshiya NagasakiMasashi Ueno
Nov 5, 2014·International Journal of Colorectal Disease·Soo Young LeeHyeong Rok Kim
Jul 21, 2016·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·F BaoG-X Li
Mar 30, 2017·World Journal of Surgical Oncology·Yue ChenSiping Ma
Jul 30, 2019·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·T SammourY N You
Jan 27, 2019·Annals of Surgical Oncology·Soo Young LeeJae Kyun Ju
Sep 25, 2020·Diseases of the Colon and Rectum·In Teak WooJong Gwang Kim
Jul 5, 2019·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Alexandra W EliasKellie L Mathis
Dec 31, 2020·Cancer Management and Research·Yaofei JiangBo Liang
Mar 8, 2021·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Zutoia BalciscuetaÁlvaro García-Granero
Aug 3, 2021·Surgery Open Science·Keegan GuidolinFayez A Quereshy
Dec 14, 2018·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·Wouter WillaertWim Ceelen

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