Prognostic Correlation of Glycolysis-Related Gene Signature in Patients with Laryngeal Cancer.

The American Journal of the Medical Sciences
Zhao DingYueming Ding

Abstract

Aerobic glycolysis is one of the metabolic characteristics of tumor cells, which is regulated by many genes. The aim of our study was to construct glycolysis-related gene signature to accurately predict the prognosis of laryngeal cancer (LC) patients. We analyzed the mRNA expression profiles of LC patients from The Cancer Genome Atlas (TCGA). Eleven glycolysis-related gene sets were analyzed by gene set enrichment analysis (GSEA). In order to acquire the gene signature related to prognosis, we used univariate and multivariate Cox regression analysis. We confirmed that a gene signature composed of two genes (STC2, LHPP) can predict the overall survival (OS) of patients with LC. Based on each patient's risk score, we found that the survival results of patients in the high-risk group were significantly lower than those in the low-risk group (log-rank test P-value=0.002). Multivariate Cox regression analysis confirmed that gene signature could independently predict OS in LC patients (HR = 1.981, 95% CI 1.446-2.714 P<0.001). In addition, a nomogram including the age, sex, grade and risk score was constructed. The nomogram demonstrated good accuracy for OS prediction, with a C-index of 0.752. The glycolysis-related two-gene risk scor...Continue Reading

References

May 23, 2009·Science·Matthew G Vander HeidenCraig B Thompson
May 15, 2013·Molecular and Cellular Endocrinology·Alice Y S Law, Chris K C Wong
Sep 12, 2015·Biochemical and Biophysical Research Communications·Yuxia WangWenhua Tan
Jan 16, 2016·Cell Metabolism·Natalya N Pavlova, Craig B Thompson
Jun 2, 2016·Canadian Journal of Physiology and Pharmacology·Qiong YuanXin-Chu Yuan
Nov 24, 2016·Molecular Medicine Reports·Juan ZhouYang Hong
Nov 30, 2016·CA: a Cancer Journal for Clinicians·Conor E SteuerNabil F Saba
Dec 3, 2016·Biochemical Society Transactions·Michelle PotterKarl J Morten
Mar 1, 2017·Journal of Cellular and Molecular Medicine·Hengqiang ZhaoTao Yin
Mar 22, 2018·Nature·Sravanth K HindupurMichael N Hall
Jun 1, 2018·Combinatorial Chemistry & High Throughput Screening·YaQi LiLiucun Zhu
Jun 27, 2018·Biochemical and Biophysical Research Communications·Jiangli ZhengLizhou Sun
Oct 18, 2018·Journal of Cancer Research and Clinical Oncology·Qiang LiWei-Xi Shen
Jan 21, 2019·Pathology Oncology Research : POR·Hulya Ayik AydinTayup Simsek
Mar 14, 2019·OncoTargets and Therapy·Chunxiao ZhangBin Xiong
Nov 7, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Shangnan DaiYi Miao
Jan 30, 2020·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Sílvia PetrarolhaMarco Kulcsar
Mar 21, 2020·Chinese Journal of Cancer Research = Chung-kuo Yen Cheng Yen Chiu·Yutong HeJie He

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