Prognostic determinants in conventionally treated myocarditis and perimyocarditis--focus on antimyolemmal antibodies

European Heart Journal
B MaischK Kochsiek

Abstract

In this study from two specialized centres 85 patients with histologically proven myocarditis (n = 10) and clinically ascertained perimyocarditis (pericardial effusion and cardiomegaly or segmental wall motion abnormality; n = 75) were followed up for 4.5 + 1.9 years. Immunosuppressive treatment was not applied. After a mean follow-up period of 4.5 + 1.9 years 55% of patients had improved clinically and 35% of patients were completely free of symptoms. Relapses had occurred up to three times. Chronic forms were found in 20% of patients, mostly in those with pericarditis and effusions. Eighteen percent of the patients deteriorated gradually. In 20% of the chronic or deteriorating patients congestive heart failure developed (postmyocarditic heart muscle disease). Fifteen percent of the patients died, mainly from bacterial perimyocarditis and to a lesser extent from inflammatory heart disease from enteroviruses. Patients who succumbed after more than 6 months died either suddenly or from progressive heart failure. A favourable outcome was often accompanied by a decrease in titre, but this decrease was less impressive in those who had antimyolemmal and antisarcolemmal antibodies. The persistence of these antibodies in high titres p...Continue Reading

Citations

Dec 21, 2006·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·R Dalla PozzaH Netz
Oct 1, 1993·Journal of the American College of Cardiology·M J Sole, P Liu
Jan 1, 1976·Transplantation Reviews·R T Prehn
Nov 24, 2011·Heart Failure Clinics·Bernhard MaischSabine Pankuweit
Aug 25, 2020·The Cochrane Database of Systematic Reviews·Joan RobinsonTerry P Klassen
May 21, 2015·The Cochrane Database of Systematic Reviews·Joan RobinsonTerry P Klassen
Dec 5, 2002·Angiology·Tomohiro HaradaSaichi Hosoda

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