Abstract
The aim of the study was to evaluate the prognostic significance of tumor geography, defined as exophytic or barrel-shaped growth, in bulky (>4 cm) cervical cancer. Four hundred women with cervical cancer, treated by primary radical hysterectomy between January 1984 and November 2000, were followed in a prospective cohort study. Clinical and pathology data were stored in a databank and the clinical protocol was unchanged during the study except for the amendment of additional indications of postoperative radiation in 1997. The assessment of tumor geography was based on pelvic examination at the time of tumor staging or radical hysterectomy or from the pathology report. Survival probabilities were calculated by the Kaplan-Meier method and compared with the log-rank test. The mean age of the patients was 45 years and the mean follow-up duration 48 months. Tumors were of squamous cell type in 291 patients (73%). Lymph node metastases were present in 91 patients (24%) and postoperative radiation was given in 179 patients (45%). In 291 patients, tumor diameter was <4 cm; in 58 patients, the tumor was defined as bulky exophytic and in 51 patients as bulky barrel shaped. There were no differences among these three groups in terms of o...Continue Reading
References
Oct 1, 1992·Gynecologic Oncology·J D BlossP J DiSaia
Aug 1, 1992·Cancer·E BurghardtJ Haas
Sep 1, 1990·Gynecologic Oncology·G DelgadoF Major
Aug 1, 1995·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
Jan 1, 1994·International Journal of Radiation Oncology, Biology, Physics·P J EifelM J Oswald
Aug 23, 1997·Lancet·F LandoniC Mangioni
Apr 15, 1999·The New England Journal of Medicine·H M KeysD Gersell
Apr 15, 1999·The New England Journal of Medicine·G M Thomas
Aug 26, 1999·The New England Journal of Medicine
Sep 10, 1999·Gynecologic Oncology·B A GoffB E Greer
Feb 24, 2000·Gynecologic Oncology·P J PaleyW J Koh
Apr 14, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W A PetersD S Alberts
Sep 12, 2001·The Surgical Clinics of North America·J E Sardi
Jul 1, 1995·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·N.F. HackerJ.L. Nicklin
Aug 21, 2003·Lancet·Valerie Beral, UNKNOWN Million Women Study Collaborators
Oct 16, 2003·Maturitas·P G Crosignani
Aug 29, 2006·International Journal of Clinical Oncology·Takafumi Toita
Citations
Feb 20, 2010·Journal of Cancer Research and Clinical Oncology·Lars-Christian HornBettina Hentschel
Mar 17, 2010·Surgical Oncology·Taner TuranMehmet Faruk Kose
Nov 5, 2015·International Journal of Radiation Oncology, Biology, Physics·Kenji YoshidaRichard Pötter
Sep 3, 2013·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Saha YooMasahide Ohmichi
Jul 23, 2013·PloS One·Sabrina A H M van den TillaartJan Oosting
Jul 13, 2017·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·W Glenn McCluggageLynn Hirschowitz
Mar 18, 2011·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·David CibulaPavel Dundr
May 3, 2013·Obstetrics and Gynecology·Neville F HackerMichael Jackson
Jun 16, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Emel CanazVolkan Ulker
Dec 8, 2011·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Xiaojian YanFeiyun Zheng
May 13, 2019·International Journal of Clinical Oncology·Shintaro TsuruokaTeruhito Mochizuki
Feb 12, 2021·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Kay J ParkW Glenn McCluggage
Aug 25, 2021·Best Practice & Research. Clinical Obstetrics & Gynaecology·Neerja BhatlaLalit Kumar