Prognostic difference of surgical treatment of exophytic versus barrel-shaped bulky cervical cancer

Gynecologic Oncology
J B TrimbosG G Kenter

Abstract

The aim of the study was to evaluate the prognostic significance of tumor geography, defined as exophytic or barrel-shaped growth, in bulky (>4 cm) cervical cancer. Four hundred women with cervical cancer, treated by primary radical hysterectomy between January 1984 and November 2000, were followed in a prospective cohort study. Clinical and pathology data were stored in a databank and the clinical protocol was unchanged during the study except for the amendment of additional indications of postoperative radiation in 1997. The assessment of tumor geography was based on pelvic examination at the time of tumor staging or radical hysterectomy or from the pathology report. Survival probabilities were calculated by the Kaplan-Meier method and compared with the log-rank test. The mean age of the patients was 45 years and the mean follow-up duration 48 months. Tumors were of squamous cell type in 291 patients (73%). Lymph node metastases were present in 91 patients (24%) and postoperative radiation was given in 179 patients (45%). In 291 patients, tumor diameter was <4 cm; in 58 patients, the tumor was defined as bulky exophytic and in 51 patients as bulky barrel shaped. There were no differences among these three groups in terms of o...Continue Reading

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Citations

Feb 20, 2010·Journal of Cancer Research and Clinical Oncology·Lars-Christian HornBettina Hentschel
Sep 3, 2013·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Saha YooMasahide Ohmichi
Jul 23, 2013·PloS One·Sabrina A H M van den TillaartJan Oosting
Jul 13, 2017·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·W Glenn McCluggageLynn Hirschowitz
Mar 18, 2011·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·David CibulaPavel Dundr
May 3, 2013·Obstetrics and Gynecology·Neville F HackerMichael Jackson
Jun 16, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Emel CanazVolkan Ulker
Dec 8, 2011·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Xiaojian YanFeiyun Zheng
Feb 12, 2021·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Kay J ParkW Glenn McCluggage
Aug 25, 2021·Best Practice & Research. Clinical Obstetrics & Gynaecology·Neerja BhatlaLalit Kumar

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