Prognostic effect of perioperative change of serum carcinoembryonic antigen level: a useful tool for detection of systemic recurrence in rectal cancer

Annals of Surgical Oncology
Yoon-Ah ParkChang Whan Cho

Abstract

The prognosis of patients even with the same stage of rectal cancer varies widely. We analyzed the capability of perioperative change of serum carcinoembryonic antigen (CEA) level for predicting recurrence and survival in rectal cancer patients. We reviewed 631 patients who underwent potentially curative resection for stage II or III rectal cancer. Patients were categorized into three groups according to their serum CEA concentrations on the seventh day before and on the seventh day after surgery: group A, normal CEA level (<or=5 ng/mL) in both periods; group B, increased preoperative and normal postoperative CEA; and group C, continuously increased CEA in both periods. The prognostic relevance of the CEA group was investigated by analyses of recurrence patterns and survival. Stage III patients showed higher systemic recurrence (P = .001) and worse 5-year survival rates (P < .0001) for group C than for groups A and B. On multivariate analysis, the CEA group was a significant predictor for recurrence (P < .001; relative risk, 2.740; 95% confidence interval, 1.677-4.476) and survival (P = .001; relative risk, 2.174; 95% confidence interval, 1.556-3.308). The perioperative serum CEA change was a useful prognostic indicator to pred...Continue Reading

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Citations

Mar 5, 2009·International Journal of Colorectal Disease·V Moreno GarcíaE Casado
Aug 23, 2008·World Journal of Gastroenterology : WJG·Ze-Yu WuHua-Huan Lin
Mar 16, 2006·Annals of Surgical Oncology·Timothy J Yeatman
Oct 7, 2006·Annals of Surgical Oncology·Donn C Young
Jun 15, 2013·Journal of Cancer Research and Clinical Oncology·Jung Wook HuhYoung Jin Kim
Nov 27, 2015·International Journal of Colorectal Disease·Chien-Liang LaiCheng-Wen Hsiao
Oct 1, 2014·Indian Journal of Cancer·G AggarwalS Banerjee
Dec 18, 2010·Asian Journal of Surgery·Anis Kausar GhazaliZainal Mahmood
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Sep 17, 2009·Journal of Surgical Oncology·Hsiang-Lin TsaiJaw-Yuan Wang
Dec 6, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yeon-Joo KimTae Hyun Kim
Mar 17, 2015·International Journal of Surgery·Imran BhattiGiuseppe Garcea
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Aug 11, 2019·Journal of Ovarian Research·Bing XinXiao-Dong Zhao

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