Prognostic effect of response to interferon therapy after laparoscopic splenectomy among patients with marked thrombocytopenia and hepatitis C virus-related cirrhosis

Hepatology International
Hideyuki TamaiMasao Ichinose

Abstract

Laparoscopic splenectomy enables patients with marked thrombocytopenia and hepatitis C virus (HCV)-related cirrhosis to receive sufficient interferon-based therapy. The purpose of this study was to evaluate whether the response to interferon after laparoscopic splenectomy contributes to the survival of cirrhotic patients with marked thrombocytopenia. Eighty-seven patients with marked thrombocytopenia and HCV-related cirrhosis who met the inclusion criteria were enrolled. Of the 87 patients, 65 underwent laparoscopic splenectomy for IFN therapy, and 22 patients declined laparoscopic splenectomy and IFN therapy. Finally, 61 patients received IFN therapy after splenectomy, and 26 patients did not receive IFN therapy. The numbers of patients in the sustained virological response (SVR) group, the transient response (TR) group, the no response (NR) group, and the no interferon (IFN) group were 25, 12, 24, and 26, respectively. Seven-year survival in the SVR group, the TR group, NR group, and the no IFN group was 86, 76, 44, and 42%, respectively. When the response group was defined as the SVR or TR group, survival was significantly higher for the response group than for the other groups. However, there was no significant difference b...Continue Reading

References

Nov 30, 2007·The New England Journal of Medicine·John G McHutchisonUNKNOWN TPL102357 Study Group
Jan 12, 2008·World Journal of Gastroenterology : WJG·Takehiro Okabayashi, Kazuhiro Hanazaki
Feb 12, 2009·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Daisuke MoriharaHiromitu Kumada
Sep 18, 2009·Nature·David L ThomasMary Carrington
Nov 3, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Ashwani K SingalGagan K Sood
Jul 27, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Paul J PockrosAnna S Lok
Oct 5, 2010·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Satoru ImuraEiji Takeda
Mar 5, 2011·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver
Jul 29, 2011·Journal of Gastroenterology and Hepatology·Tomohiko AkahoshiYoshihiko Maehara
Jan 1, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Vincenzo Boccaccio, Savino Bruno

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Citations

Nov 14, 2019·Transactions of the Royal Society of Tropical Medicine and Hygiene·Ahmed NagatyEkram W Abd El-Wahab

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