Abstract
Previous heart failure (HF) risk models have included clinical and noninvasive variables and have been derived largely from clinical trial databases or decompensated HF registries. The importance of hemodynamic assessment is less established, particularly in ambulatory patients with advanced HF. In this study, 513 consecutive ambulatory patients (mean age 54+/-11 years, mean left ventricular ejection fraction 20+/-9%) with symptomatic HF who underwent diagnostic right-sided cardiac catheterization as part of outpatient assessment from 2000 to 2005 were reviewed. After a total of 1,696 patient-years of follow-up, 139 (27%) patients had died and 116 (23%) had undergone cardiac transplantation. The 1- and 2-year overall survival rates (defined as freedom from death or cardiac transplantation) were 77% and 67%, respectively. Overall, 65% of patients had elevated intracardiac filling pressures, and 40% had cardiac indexes<2.2 L/min/m2. In multivariate analysis, mean pulmonary arterial pressure, cardiac index, and the severity of mitral regurgitation were the 3 strongest predictors of all-cause mortality and cardiac transplantation. Renal dysfunction was also an independent predictor of all-cause mortality. When a clinical model for ...Continue Reading
References
Mar 15, 1992·Journal of the American College of Cardiology·G C FonarowE Albanese
Aug 1, 1991·The New England Journal of Medicine·UNKNOWN SOLVD InvestigatorsJay N Cohn
Oct 15, 1989·Annals of Internal Medicine·R K BurtC T Van Buren
Nov 1, 1994·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·S KaulP J Sabia
Aug 19, 1997·Circulation·A E SteimleJ H Tillisch
Apr 9, 1998·Transplantation Proceedings·M N WicksA O Gaber
Sep 2, 1999·The New England Journal of Medicine·B PittJ Wittes
Mar 15, 2000·Journal of the American College of Cardiology·D L DriesL W Stevenson
Aug 10, 2000·European Journal of Heart Failure·L W Stevenson
Feb 5, 2004·American Heart Journal·Javed ButlerHarlan M Krumholz
Feb 27, 2004·The American Journal of Medicine·James M BrophySalim Yusuf
Mar 9, 2005·The New England Journal of Medicine·John G F ClelandUNKNOWN Cardiac Resynchronization-Heart Failure (CARE-HF) Study Investigators
Apr 23, 2005·American Heart Journal·Kirkwood F AdamsUNKNOWN ADHERE Scientific Advisory Committee and Investigators
Mar 15, 2006·Circulation·Wayne C LevyMilton Packer
Sep 12, 2006·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Mandeep R MehraMark Barr
Feb 13, 2007·The American Journal of Cardiology·Claudia YpenburgLieselot van Erven
Citations
Jun 9, 2012·European Heart Journal·Wai Hong Wilson TangJames Thomas Heywood
Jun 30, 2010·International Journal of Clinical Practice·G A MacGowanG Parry
Jan 27, 2012·Circulation. Heart Failure·Mark W VogelHorng H Chen
Sep 13, 2014·The American Journal of Cardiology·Chetan B PatelJoseph G Rogers
Jul 28, 2013·Cardiovascular Drugs and Therapy·Martín J García-GonzálezUNKNOWN LAICA study investigators
Nov 26, 2010·Circulation. Cardiovascular Quality and Outcomes·Eileen HsichMichael S Lauer
Jun 29, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Laurent PlantierMichel Fournier
May 17, 2012·Congestive Heart Failure·Sharayne MarkMichael W Fong
Feb 14, 2012·The American Journal of Cardiology·Robert J MentzChristopher M O'Connor
Apr 30, 2015·European Journal of Heart Failure·Justin L GrodinW H Wilson Tang
Oct 7, 2016·ESC Heart Failure·Tobias TägerLutz Frankenstein
Jul 8, 2015·The American Journal of Cardiology·Neha HarwaniVinay Thohan
Mar 1, 2012·International Journal of Cardiology·Luciana G C Vilas BoasPaulo R Nogueira
Jul 7, 2016·Circulation. Heart Failure·Scott J DenardoChristopher M O'Connor
Mar 12, 2017·Circulation. Heart Failure·Mohamed HassanMagdi H Yacoub
Apr 5, 2014·Journal of Cardiovascular Medicine·Gabriella MalfattoGianfranco Parati
Nov 19, 2019·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Yan WenPascal Spincemaille
Oct 10, 2020·Journal of Cardiac Failure·Nduka C OkwoseDjordje G Jakovljevic
Aug 11, 2021·Journal of Magnetic Resonance Imaging : JMRI·Tilman EmrichAurelio Secinaro
Oct 31, 2021·ESC Heart Failure·Martín J García-GonzálezAlejandro Jiménez Sosa