Prognostic evaluation of ambulatory patients with advanced heart failure

The American Journal of Cardiology
Wilfried MullensW H Wilson Tang

Abstract

Previous heart failure (HF) risk models have included clinical and noninvasive variables and have been derived largely from clinical trial databases or decompensated HF registries. The importance of hemodynamic assessment is less established, particularly in ambulatory patients with advanced HF. In this study, 513 consecutive ambulatory patients (mean age 54+/-11 years, mean left ventricular ejection fraction 20+/-9%) with symptomatic HF who underwent diagnostic right-sided cardiac catheterization as part of outpatient assessment from 2000 to 2005 were reviewed. After a total of 1,696 patient-years of follow-up, 139 (27%) patients had died and 116 (23%) had undergone cardiac transplantation. The 1- and 2-year overall survival rates (defined as freedom from death or cardiac transplantation) were 77% and 67%, respectively. Overall, 65% of patients had elevated intracardiac filling pressures, and 40% had cardiac indexes<2.2 L/min/m2. In multivariate analysis, mean pulmonary arterial pressure, cardiac index, and the severity of mitral regurgitation were the 3 strongest predictors of all-cause mortality and cardiac transplantation. Renal dysfunction was also an independent predictor of all-cause mortality. When a clinical model for ...Continue Reading

References

Aug 1, 1991·The New England Journal of Medicine·UNKNOWN SOLVD InvestigatorsJay N Cohn
Oct 15, 1989·Annals of Internal Medicine·R K BurtC T Van Buren
Nov 1, 1994·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·S KaulP J Sabia
Apr 9, 1998·Transplantation Proceedings·M N WicksA O Gaber
Aug 10, 2000·European Journal of Heart Failure·L W Stevenson
Feb 27, 2004·The American Journal of Medicine·James M BrophySalim Yusuf
Mar 9, 2005·The New England Journal of Medicine·John G F ClelandUNKNOWN Cardiac Resynchronization-Heart Failure (CARE-HF) Study Investigators
Mar 15, 2006·Circulation·Wayne C LevyMilton Packer
Sep 12, 2006·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Mandeep R MehraMark Barr
Feb 13, 2007·The American Journal of Cardiology·Claudia YpenburgLieselot van Erven

❮ Previous
Next ❯

Citations

Jun 9, 2012·European Heart Journal·Wai Hong Wilson TangJames Thomas Heywood
Jun 30, 2010·International Journal of Clinical Practice·G A MacGowanG Parry
Jan 27, 2012·Circulation. Heart Failure·Mark W VogelHorng H Chen
Nov 26, 2010·Circulation. Cardiovascular Quality and Outcomes·Eileen HsichMichael S Lauer
Jun 29, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Laurent PlantierMichel Fournier
May 17, 2012·Congestive Heart Failure·Sharayne MarkMichael W Fong
Apr 30, 2015·European Journal of Heart Failure·Justin L GrodinW H Wilson Tang
Mar 1, 2012·International Journal of Cardiology·Luciana G C Vilas BoasPaulo R Nogueira
Apr 5, 2014·Journal of Cardiovascular Medicine·Gabriella MalfattoGianfranco Parati
Oct 31, 2021·ESC Heart Failure·Martín J García-GonzálezAlejandro Jiménez Sosa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.