PMID: 9001978Dec 1, 1996Paper

Prognostic evaluation of specific cutaneous infiltrates in B-chronic lymphocytic leukemia

Journal of Cutaneous Pathology
S KadduH Kerl

Abstract

The relationship between numerous histologic variables and survival was investigated in 54 consecutive lesions of specific skin infiltrates of B-cell chronic lymphocytic leukemia (B-CLL) from 27 patients (16 males and 11 females, mean age 65 years, range 42-83 years). All patients were followed for up to 204 months or until death. Histopathologically, the infiltrates showed a patchy perivascular (35%), diffuse (31.5%), nodular (31.5%) or bandlike (1.9%) pattern. In 28% of the cases, an admixture of reactive cells within the infiltrate including eosinophils, histiocytes, neutrophils and plasma cells was observed. Cytomorphologically, small B-lymphocytes with condensed chromatin predominated in most infiltrates. However, some biopsies showed a small but significant number of medium- or large-sized neoplastic cells of the B-lymphocyte lineage with variable cytomorphological features. In a multivariate analysis, several histologic parameters within the infiltrates were found to show a significant association with long survival, namely, an infiltrate of moderate density, a nodular pattern, involvement of the lower dermis only, and presence of predominantly small B-lymphocytes (more than 95%) with condensed chromatin. Histologic vari...Continue Reading

References

Jan 1, 1978·Cancer·F R Dick, R D Maca
Jan 1, 1988·Advances in Experimental Medicine and Biology·L A LiottaM Sobel
Apr 1, 1985·The American Journal of Dermatopathology·S A BuechnerW P Su
Apr 1, 1984·The Journal of Dermatologic Surgery and Oncology·D BonvaletJ Civatte
Jul 1, 1984·Journal of the American Academy of Dermatology·W P SuC Y Li
Oct 1, 1993·Journal of Cutaneous Pathology·J K Desch, B R Smoller
Sep 1, 1993·American Journal of Clinical Pathology·T A Longacre, B R Smoller

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Citations

Jan 21, 2006·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·C SuckerM Stockschläder
Jan 20, 2012·The American Journal of Dermatopathology·Cheryl LevinUma Sundram
Nov 5, 2016·International Journal of Dermatology·Erica ShanthaEdward Esparza
Aug 25, 2020·The American Journal of Dermatopathology·Eduardo Rozas-MuñozMaria P García-Muret
Sep 6, 2020·International Journal of Hematology·Elena A MorozovaEugene A Nikitin
Oct 20, 2004·The Journal of Dermatology·Takaharu IkedaFukumi Furukawa
Jun 25, 2004·The British Journal of Dermatology·K L AgnewC B Bunker
Jun 13, 2009·Journal of Cutaneous Pathology·Paul J CraigCatherine M Stefanato
Jan 28, 2014·Journal of Cutaneous Pathology·S KindemO Sanmartin
Aug 27, 2005·The British Journal of Dermatology·F BenedixM Berneburg
May 27, 2021·International Journal of Dermatology·Catarina CorreiaPaulo Filipe

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