Prognostic factors affecting survival in non-small cell lung carcinoma patients with malignant pleural effusions

The Clinical Respiratory Journal
Umut Sabri KasapogluArmagan Hazar

Abstract

Lung cancer is the most common cause of malignant pleural effusions (MPEs). For patients with lung cancer and MPE, median survival is only 3-4 months. The aim of this study was to evaluate lung cancer patients with MPE by clinical and laboratory findings on admission, and determine 2-year survival rate and prognostic factors. Between 2008 and 2011, we examined 199 cases of non-small cell lung carcinoma with MPE. Demographic factors of patients, tumor characteristics, treatment delivered and laboratory parameters affecting prognosis were evaluated. Survival rates were estimated by Kaplan-Meier method. Significance of each prognostic factors selected by univariate analysis were confirmed using Cox regression model. The study included 139 (69.8%) male and 60 (30.2%) female patients with a median age of 64 (30-85) years. Median overall survival was 4.4 months. Adenocarcinoma was the leading cause of MPE with 80.4%. A univariate analysis showed that factors affecting mortality included gender (P < 0.001), MPE with distant metastasis (P = 0.025), lower serum albumin (P < 0.0001), lower pleural protein (P < 0.0001), increased serum lactate dehydrogenase (P = 0.003), increased serum C-reactive protein (CRP) (P < 0.0001), increased whit...Continue Reading

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Citations

Apr 21, 2017·Current Opinion in Pulmonary Medicine·Labib G Debiane, David E Ost
Jul 12, 2017·Cancers·Ilija NenadićOliver Schildgen
Aug 16, 2018·Journal of Oncology Practice·Theresa S YangDong W Chang
Apr 5, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Janet Rodríguez-TorresMarie Carmen Valenza
Nov 16, 2017·Oncotarget·Carl-Olof HillerdalAnders Hjerpe
Aug 18, 2020·Journal of Bronchology & Interventional Pulmonology·Russell J MillerRoberto F Casal
Jan 30, 2021·Future Oncology·Larissy Machado da SilvaLuiz Claudio Santos Thuler

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