Prognostic factors after hepatic resection for hepatocellular carcinoma with hepatitis C viral infection: univariate and multivariate analysis

The American Journal of Gastroenterology
K HanazakiJ Amano

Abstract

Although the incidence of hepatocellular carcinoma (HCC) with hepatitis C virus (HCV) infection is higher than in patients with hepatitis B virus (HBV)-related HCC in Japan, the long-term prognosis and prognostic factors of HCV-related HCC after hepatic resection are poorly understood. The surgical outcome of HCV-related HCC in 172 consecutive patients who underwent hepatic resection between 1989 and 1997 was retrospectively clarified. Postresection prognostic factors were evaluated by univariate and multivariate analysis using Cox's proportional hazards model. The overall incidence of postoperative complications was 23.2%, and 11 patients among that group had hospital deaths (6.4%) including 9 (5.2%) operative deaths. The mean and median overall survivals including hospital death after surgery were 41 months and 33 months, respectively. The 3-, 5-, and 7-yr overall survival rates after hepatic resection were 63%, 52%, and 47%, respectively. The 3-, 5-, and 7-yr disease-free survival rates after hepatic resection were 33%, 20%, and 15%, respectively. Multivariate analysis revealed that serum alpha-fetoprotein (AFP) of > or = 1000 ng/ml and the presence of vascular invasion were independent unfavorable prognostic factors affecti...Continue Reading

References

May 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K Okuda
Oct 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K KiyosawaR H Purcell
Oct 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y ShiratoriM Ohashi
Jun 24, 1993·The New England Journal of Medicine·H TsukumaH Yamazaki
Jan 1, 1995·American Journal of Surgery·J N VautheyM Brennan
Jun 1, 1994·Gut·S Sherlock
Aug 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S MiyagawaM Makuuchi
Mar 11, 1999·The New England Journal of Medicine·H B El-Serag, A C Mason
Dec 3, 1999·The British Journal of Surgery·C C WuF K P'eng
Feb 3, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M F YuenC L Lai
Oct 1, 1908·Annals of Surgery·J H Pringle

❮ Previous
Next ❯

Citations

Sep 22, 2005·Journal of Gastroenterology and Hepatology·Junji FuruseMasahiro Yoshino
Aug 30, 2008·World Journal of Gastroenterology : WJG·Atsushi NanashimaTakeshi Nagayasu
Nov 1, 2016·Journal of Gastroenterology and Hepatology·Eung Chang LeeSang-Jae Park
Mar 12, 2008·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Eldad S Bialecki, Adrian M Di Bisceglie
Apr 2, 2002·The American Journal of Gastroenterology·Motoh IwasaSusumu Teraguchi
Apr 17, 2009·World Journal of Gastroenterology : WJG·Zheng ShiYou-Ting Chen
Sep 15, 2009·World Journal of Gastroenterology : WJG·Murad AljiffryMichele Molinari
Dec 17, 2009·World Journal of Gastroenterology : WJG·Wei-Feng ShenJia-Mei Yang
May 29, 2008·World Journal of Gastroenterology : WJG·Mirna H FarhatKassem A Barada
Dec 17, 2010·World Journal of Gastrointestinal Surgery·Dongil ChoiHyunchul Rhim
Aug 17, 2004·The American Journal of Gastroenterology·Kuo-Shyang JengYi-Chun Tsai
Sep 2, 2003·Journal of Surgical Oncology·Vincent DonckierMichel Gelin
Oct 11, 2011·Journal of Hepato-biliary-pancreatic Sciences·Yukiyasu OkamuraKatsuhiko Uesaka
Jan 5, 2002·The American Journal of Surgical Pathology·Gregory Y LauwersUNKNOWN International Cooperative Study Group on Hepatocellular Carcinoma
Sep 21, 2007·Journal of Clinical Gastroenterology·Laura M KulikRiad Salem
Jun 25, 2008·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Takatoshi IshikoHideo Baba
Oct 13, 2005·Virchows Archiv : an International Journal of Pathology·David MondadaWalter K F Seelentag
Apr 11, 2007·Digestive Diseases and Sciences·Mari KogoKeiichiro Yoneyama
Sep 30, 2009·Journal of Hepato-biliary-pancreatic Sciences·Hiroji ShinkawaShoji Kubo
Feb 6, 2018·World Journal of Hepatology·Omer EkinciSabahattin Kaymakoglu
Nov 20, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Shigeki NakagawaHideo Baba
Oct 9, 2016·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Shogo TanakaShoji Kubo
Jan 28, 2006·World Journal of Gastroenterology : WJG·Bong-Wan KimMyung-Wook Kim
May 2, 2018·The American Journal of Gastroenterology·Ruben Hernaez, Hashem B El-Serag
Nov 20, 2019·Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences·Arash SarveazadMansour Bahardoust

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.