Prognostic factors after repeat hepatectomy for recurrent hepatocellular carcinoma

Annals of Surgery
M ShimadaK Sugimachi

Abstract

The aims of this study were to identify prognostic factors in patients who developed recurrent hepatocellular carcinoma (HCC) after repeat hepatectomy and to elucidate the role of multicentric occurrence in the second tumor after a first hepatectomy. A repeat hepatectomy for recurrent HCC has been established as the most effective treatment modality, whenever it is possible. However, the prognostic factors for recurrent HCC after repeat hepatectomy have yet to be clarified. Forty-one patients who underwent a curative repeat hepatectomy were retrospectively studied. Patient survival and disease-free survival after recurrence were univariately and multivariately analyzed using 38 clinicopathologic variables. The histologic grade of HCC at repeat hepatectomy was also compared with that at first hepatectomy. Patient survival after repeat hepatectomy did not differ substantially from that in 312 patients undergoing primary hepatectomy. However, the disease-free survival after repeat hepatectomy was significantly lower than that in patients with only a primary hepatectomy (p < 0.05). Multivariate analysis revealed only portal vein invasion in the first hepatectomy to be an independent and significantly poor prognostic factor. Regardi...Continue Reading

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Citations

Aug 19, 2011·Langenbeck's Archives of Surgery·Yoji KishiToshiharu Yamaguchi
May 11, 2011·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Fumitoshi HirokawaNobuhiko Tanigawa
Apr 6, 2004·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·W-T ChenC-W Wu
Sep 28, 2001·American Journal of Surgery·M ShimadaK Sugimachi
Jul 11, 2003·Critical Reviews in Oncology/hematology·Guillermo Marín-HargreavesHenri Bismuth
Mar 14, 2001·Journal of the American College of Surgeons·Y NakajimaH Nakano
Dec 11, 2002·Journal of Gastroenterology and Hepatology·K C Tan
Feb 1, 2002·Surgery·Taketoshi SuehiroKeizo Sugimachi
Oct 28, 2003·Annals of Surgery·Masami MinagawaNorihiro Kokudo
Mar 18, 2011·Journal of Gastroenterology and Hepatology·Wladimir FaberMarcus Bahra
Jul 2, 2010·World Journal of Surgical Oncology·Yanming ZhouZhenyu Liu
Jun 15, 2007·Annals of Surgical Oncology·Kuniya TanakaShinji Togo
Apr 23, 2010·Annals of Surgical Oncology·Akinobu TaketomiYoshihiko Maehara
Dec 29, 2011·Annals of Surgical Oncology·Yo-ichi YamashitaYoshihiko Maehara
Dec 21, 2007·AJR. American Journal of Roentgenology·Akihiro NishieHiroshi Honda
Aug 6, 2008·World Journal of Gastroenterology : WJG·Adam Bartlett, Nigel Heaton
Sep 6, 2013·Annals of Surgical Oncology·Ioannis HatzarasTimothy M Pawlik
Aug 27, 2013·Surgery·Yo-ichi YamashitaYoshihiko Maehara
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