Prognostic factors and survival study in high-grade glioma in the elderly

British Journal of Neurosurgery
Sayoa Álvarez de Eulate-BeramendiJuan Martino-González

Abstract

Background Glioblastoma multiforme (GBM) is the most common and malignant primary brain tumour in adults. Due to the ageing of the population, diagnosis in the elderly is becoming more common. The aim of this study was to analyse different combinations of treatments and to identify preoperative factors, including O6-methylguanine-DNA methyltransferase status, that may be associated with decreased survival among patients older than 70 years. Methods and materials We retrospectively included all patients over 70 years of age, who underwent surgery at the Department of Neurosurgery (HUCA and HUMV) and were diagnosed of GBM by pathological criteria from January 2007 to September 2014. Results Eighty-one patients were analysed, whose mean age was 75 (SD 4) and 48 were male. Karnofsky performance status (KPS) was over 70 in 61 patients and 38.3% presented with motor deficit. Sixty-three patients underwent resection, and 18 had only a diagnostic biopsy. The complication rate was 17.28% and mortality rate was 7.4%. Survival was increased in patients who received radiotherapy (n = 41) or additional chemotherapy (n = 26) (p < 0.001). KPS < 70 was an independent factor associated with low-rate survival. Patients with optimal treatment had...Continue Reading

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Oct 19, 2017·Neuro-oncology·Deborah ForstJustin T Jordan
Feb 3, 2018·Journal of Neuro-oncology·Michael KarsySarah T Menacho
May 6, 2017·Neurosurgery·Patrick M FlaniganManish K Aghi
Dec 20, 2019·British Journal of Neurosurgery·Elena Romana GasenzerEdmund Neugebauer

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