Prognostic factors and treatment results of high-grade osteosarcoma in norway: a scope beyond the "classical" patient

Sarcoma
Kjetil BernerOyvind Sverre Bruland

Abstract

Purpose. A retrospective study of prognostic factors and treatment outcome of osteosarcoma (OS) during modern chemotherapy era with focus on patients with primary metastatic disease, nonextremity localisation, or age >40 years (nonclassical OS). Methods. A nationwide cohort, comprising 424 high-grade Norwegian bone OS patients, was based on registry sources supplemented with clinical records from hospitals involved in sarcoma management between 1975 and 2009. Results. Only 48% were younger patients with tumour in the extremities and without metastasis at diagnosis (classical OS). A considerable discrepancy in survival between classical and nonclassical OS was observed: 61% versus 26% 10-year sarcoma specific survival. Twice as many of the former received both adequate surgery and chemotherapy compared to the latter. This could only partly explain the differences in survival due to inherent chemoresistance in primary metastatic disease and a higher rate of local relapse among patients with axial tumours. Metastasis at diagnosis, increased lactate dehydrogenase, age > 40 years, and tumour size above median value were all adverse prognostic factors for overall survival. Conclusion. We confirm a dramatic difference in outcome betwe...Continue Reading

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Citations

Nov 29, 2015·The Orthopedic Clinics of North America·Megan E Anderson
Feb 24, 2018·World Journal of Surgical Oncology·Li LinZhenhua Huang
Feb 14, 2019·Medical Sciences : Open Access Journal·Radoslav ZamborskyLubos Danisovic
Aug 14, 2019·Expert Opinion on Emerging Drugs·Claudia Maria HattingerMassimo Serra
Jan 1, 2020·Journal of Bone Oncology·Qingxi LinShoufeng Wang

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Methods Mentioned

BETA
biopsy
amputation

Software Mentioned

Stata
SPSS
EURAMOS
Euroboss

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