Abstract
This study aimed to determine prognostic factors associated with postrecurrence survival in cases with postoperative brain metastasis but with no extracranial metastasis in non-small cell lung cancer (NSCLC). Between 1992 and 2012, a total of 2832 patients underwent surgical resection for NSCLC. Among those, 86 patients had postoperative brain metastasis as the initial recurrence. Those patients were retrospectively reviewed. The median follow-up time after the initial lung resection was 24.0 months (range, 2.0-126.0 months). The median overall survival after initial lung cancer resection was 25.0 months and the median overall postrecurrence survival was 11 months. An initial lesion of adenocarcinoma (hazard ratio, 0.548; 95% confidence interval, 0.318 to 0.946; p=0.031), non-pneumonectomy, and a disease-free interval longer than 10.0 months (hazard ratio, 0.565; 95% confidence interval, 0.321-0.995; p=0.048) from the initial lung resection to the diagnosis of brain metastasis positively related to a good postrecurrence survival. Solitary brain metastasis and a size of less than 3 cm for the largest brain lesion were also positive factors for postrecurrence survival. Systemic chemotherapy for brain metastasis (hazard ratio, 0.3...Continue Reading
References
Feb 22, 1990·The New England Journal of Medicine·R A PatchellB Young
Sep 1, 1995·Cancer·E ArbitJ H Galicich
Apr 28, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·P RodrigusE Raaymakers
May 12, 2001·Chest·P BonnetteUNKNOWN Groupe Thorax
May 18, 2004·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Vladyslav GetmanMichael Rolf Mueller
Aug 11, 2004·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Akinori IwasakiMasaaki Yamamoto
Dec 29, 2004·The Annals of Thoracic Surgery·József FurákLászló Tiszlavicz
Mar 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Harvey J MamonRaphael Bueno
Feb 21, 2006·The Annals of Thoracic Surgery·Brent A WilliamsPing Yang
Jan 30, 2007·The Annals of Thoracic Surgery·Hiroshi SugimuraPeter C Pairolero
Jun 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Leslie L MuldoonEdward A Neuwelt
Dec 9, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Hyeon Gyu YiYung-Jue Bang
Apr 21, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·A OmlinM Früh
Jul 9, 2009·Chest·Frank C DetterbeckLynn T Tanoue
Jul 28, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Alessandra BearzUmberto Tirelli
Sep 29, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Mutlu DoganGuze Ozal
Dec 5, 2009·Journal of Neuro-oncology·Steven N KalkanisMark E Linskey
Mar 6, 2012·The Annals of Thoracic Surgery·Chiaki EndoTakashi Kondo
Nov 7, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·Y-L WuJ-J Yang
Dec 15, 2012·International Journal of Clinical Oncology·Jin SakamotoHiroshi Date
Mar 19, 2013·Neuro-oncology·Tali Siegal
Dec 7, 2013·The Thoracic and Cardiovascular Surgeon·Cabir YukselAyten Kayı Cangir
Dec 20, 2013·OncoTargets and Therapy·Yun FanWeimin Mao
Mar 19, 2014·Annals of Surgical Oncology·Makoto SonobeHiroshi Date
May 3, 2014·Therapeutic Advances in Medical Oncology·Chiara D'AntonioFilippo de Marinis
Aug 8, 2014·Journal of Neuro-oncology·Ling CaiLan-jun Zhang
Citations
Mar 13, 2020·Thoracic Cancer·Yuxia WangEnmin Wang
Nov 16, 2016·Physics in Medicine and Biology·Yan LiuXuejun Gu
Jul 7, 2016·Deutsches Ärzteblatt International·Kirsten SchmiederStephanie Combs
Mar 16, 2021·Frontiers in Surgery·Erkan KabaAlper Toker
Dec 2, 2017·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Zili WangXianhe Xie
Aug 28, 2017·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Elizabeth A DavidRobert J Canter