Prognostic factors for death due to invasive aspergillosis after hematopoietic stem cell transplantation: a 1-year retrospective study of consecutive patients at French transplantation centers

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
C CordonnierSociété Française de Greffe de Moelle et de Thérapie Cellulaire

Abstract

Invasive aspergillosis (IA) is a major cause of death after hematopoietic stem cell transplantation (HSCT). The goal of this retrospective and consecutive survey was to assess prognostic factors of death due to IA after HSCT at the time of diagnosis of IA. All 64 health care centers affiliated with the Société Française de Greffe de Moelle et de Thérapie Cellulaire were contacted to participate in this study of all proven or probable cases of IA that occurred among HSCT recipients in 2002. Data for 51 cases (41 involving allogeneic HSCT and 10 involving autologous HSCT) were collected from patient records and included diagnostic and therapeutic features of IA, outcome, presence of hematological disease, and transplantation data. Cox models were applied to risk factors for death attributed to IA that were initially identified using the usual tests. The proportion of deaths attributed to IA within 4 months after diagnosis was 0.62 (95% confidence interval, 0.47-0.76). Seven factors assessed at diagnosis were determined to be strongly related to death due to IA: age of 12-35 years, dissemination of IA, presence of a pleural effusion, monocyte count of <120 cells/mm3, prolonged administration of steroids within the previous 2 month...Continue Reading

References

Apr 1, 1997·Bone Marrow Transplantation·E JantunenT Ruutu
Mar 4, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P RibaudE Gluckman
Apr 9, 1999·Clinical Microbiology Reviews·J P Latgé
Apr 9, 1999·Medicine·D L Paterson, N Singh
Feb 15, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S J LinS M Teutsch
Dec 4, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S AsciogluUNKNOWN Mycoses Study Group of the National Institute of Allergy and Infectious Diseases
Feb 14, 2002·British Journal of Haematology·Rodrigo MartinoUNKNOWN alloPBSCT Infectious/Non-infectious Complications Subcommittees of the Grupo Español de Trasplante Hematopoyético (GETH)
Mar 7, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kieren A MarrLawrence Corey
Aug 9, 2002·The New England Journal of Medicine·Raoul HerbrechtUNKNOWN Invasive Fungal Infections Group of the European Organisation for Research and Treatment of Cancer and the Global Aspergillu
Dec 4, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Johan MaertensUNKNOWN Caspofungin Salvage Aspergillosis Study Group

❮ Previous
Next ❯

Citations

Aug 7, 2013·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Serdar SivginAli Unal
Jan 24, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Arlo UptonKieren A Marr
Sep 21, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David W Denning
Apr 19, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marcio Nucci, John R Perfect
Sep 24, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Yasmine NivoixRaoul Herbrecht
Jan 1, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D NeofytosK Marr
May 11, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John W BaddleyPeter G Pappas
Oct 21, 2009·The Journal of Antimicrobial Chemotherapy·C ViscoliUNKNOWN Infectious Disease Group of the EORTC
Jan 5, 2011·The Journal of Antimicrobial Chemotherapy·Livio PaganoNicole Blijlevens
Dec 4, 2010·The Pediatric Infectious Disease Journal·Valtyr S ThorsTom F W Wolfs
Jan 16, 2007·Clinical Microbiology Reviews·M A Pfaller, D J Diekema
Mar 23, 2011·Infection and Immunity·Diana Diaz-ArevaloMarkus Kalkum
Jan 1, 2009·ClinicoEconomics and Outcomes Research : CEOR·Kem P Krueger, A Christie Nelson
Aug 29, 2007·Drugs·Anurag N Malani, Carol A Kauffman
Sep 10, 2008·Drugs·Maria J G T RüpingOliver A Cornely
Sep 13, 2013·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·L DrgonaR Barnes
Mar 17, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Simone Aranha NouérElias Anaissie
Dec 17, 2009·Expert Opinion on Pharmacotherapy·Jörg J VehreschildOliver A Cornely
Sep 19, 2012·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Serdar SivginAli Unal
Dec 17, 2008·International Journal of Antimicrobial Agents·Isabel Ruiz Camps
Sep 21, 2006·Infectious Disease Clinics of North America·Penelope D Barnes, Kieren A Marr
Feb 13, 2008·Transplant Infectious Disease : an Official Journal of the Transplantation Society·E JantunenV-J Anttila
Jul 4, 2007·Transplant Infectious Disease : an Official Journal of the Transplantation Society·J SinkóT Masszi
Nov 6, 2007·British Journal of Haematology·Penelope D Barnes, Kieren A Marr
Dec 14, 2011·Clinical Transplantation·Manuela Aguilar-GuisadoUNKNOWN Spanish Network for Research in Infectious Diseases
Feb 26, 2010·Transplant Infectious Disease : an Official Journal of the Transplantation Society·P ZhangM-Z Han
Feb 26, 2013·Transplant Infectious Disease : an Official Journal of the Transplantation Society·D NeofytosK A Marr
Nov 20, 2015·Journal of the Pediatric Infectious Diseases Society·Rachel L WattierWilliam J Steinbach

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.