Prognostic factors for patients with advanced non-small cell lung cancer treated with gemcitabine-platinum as first-line therapy in an observational setting in China

Thoracic Cancer
Wenyu YeShukui Qin

Abstract

This study examined the prognostic factors associated with survival in advanced non-small cell lung cancer (NSCLC) patients receiving gemcitabine-platinum regimens as first-line therapy in real-world clinical settings in China. Data was analyzed from a multinational, prospective, non-interventional, observational study of individuals receiving gemcitabine-platinum regimens as first-line therapy for NSCLC, focusing on 300 patients from mainland China. A Cox regression model was used to determine the association of 38 prognostic factors, including patient smoking characteristics, with overall survival. In these 300 patients, the mean age was 58.9 (±10.8) years, with males comprising 71% of the population. Thirty percent of patients had an Eastern Cooperative Oncology Group performance status (PS) of 0 and 70% had a PS of 1. The majority of patients had NSCLC of adenocarcinoma origin (57%). Multivariate Cox regression analyses adjusted for baseline factors revealed that gender, tumor (T) staging, metastasis (M) staging, liver metastases, serum albumin, and superior vena cava obstruction were significant prognostic factors. Smoking during therapy was not significantly associated with survival, although numbers were small for this v...Continue Reading

References

Sep 13, 2002·Chest·Michael D BrundageWilliam J Mackillop
Sep 26, 2003·Seminars in Surgical Oncology·Merrill J Solan, Maria Werner-Wasik
Feb 5, 2010·The Lancet Oncology·Brigette By MaTony Sk Mok
Jul 2, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Myung-Ju AhnSai-Hong Ignatius Ou
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Apr 7, 2011·Chest·Xiaocong FangChunxue Bai
May 15, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Cong XueLi Zhang

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Citations

Nov 28, 2015·Journal of Cancer Research and Therapeutics·Xu LiBin Ai

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