Prognostic factors for pulmonary metastasectomy in hepatocellular carcinoma

Annals of Surgical Oncology
Shuenn-Wen KuoYung-Chie Lee

Abstract

To identify the prognostic factors for pulmonary metastasectomy (PM-ectomy) in hepatocellular carcinoma (HCC). We conducted a retrospective review of patients with pulmonary metastases (PM) from HCC who had undergone curative PM-ectomy at National Taiwan University Hospital between 1990 and 2004. Univariate (log-rank) and multivariate (Cox's model) analyses of survival were used to identify the significant prognostic factors. In total, 34 patients were eligible for curative PM-ectomy. The overall survival rates (Kaplan-Meier) after PM-ectomy were 65.2% and 27.5% at 2 and 5 years, respectively. High alpha-fetoprotein level, positive hepatic resection margin, and short disease-free interval (DFI) were unfavorable factors for overall survival from univariate analysis, however, only DFI (P = 0.028) was identified as an independently prognostic factor by multivariate analysis. Bilateral distribution and more PMs were unfavorable factors for PM-free survival from univariate analysis, with only PM number identified as an independent prognostic factor by multivariate analysis (P = 0.017). Patients with longer DFIs and fewer PMs can benefit from PM-ectomy in HCC.

References

Jun 5, 2013·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Thomas SchweigerKonrad Hoetzenecker
May 5, 2010·World Journal of Gastroenterology : WJG·Tiffany Cho-Lam WongChi-Fai Ng
Jun 2, 2012·World Journal of Gastroenterology : WJG·Tian YangMeng-Chao Wu
Jul 6, 2011·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Kentaro KitanoJun Nakajima
Aug 1, 2008·World Journal of Surgery·Fengshi ChenHiroshi Date
Jul 1, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Sukki ChoEung Bae Lee
Oct 14, 2011·International Journal of Hepatology·Yoji KishiNorihiro Kokudo
Aug 27, 2015·World Journal of Surgery·Shinjiro MizuguchiShoji Kubo
May 3, 2011·Journal of Vascular and Interventional Radiology : JVIR·Takao HirakiSusumu Kanazawa
Mar 15, 2011·Surgical Oncology·Terence C Chua, David L Morris
May 20, 2016·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Naoya KawakitaAkira Tangoku
Jun 24, 2016·Journal of Surgical Oncology·Yaniv BergerUmut Sarpel
May 23, 2015·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Korean Liver Cancer Study Group (KLCSG), National Cancer Center, Korea (NCC)
Sep 29, 2009·The Korean Journal of Hepatology·Korean Liver Cancer Study Group and National Cancer Center, Korea
Jun 3, 2010·Annals of Surgical Oncology·Yoo Sang YoonKwhanmien Kim
Oct 7, 2008·World Journal of Gastroenterology : WJG·Jong-Bum KwonHyeon-Woo Lim
Jun 4, 2016·World Journal of Surgery·Yusuke TakahashiMetastatic Lung Tumor Study Group of Japan
Aug 31, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Yan-Ming ZhouJia-Mei Yang
Apr 9, 2015·World Journal of Gastroenterology : WJG·Hyung Joon YimSoon Ho Um

Citations

Dec 1, 1992·Archives of Surgery·G T VerazinH Takita
Sep 1, 1987·Journal of Surgical Oncology·Y T Lee, D A Geer
Oct 1, 1984·The Annals of Thoracic Surgery·C F MountainK E Hermes
Jun 1, 1995·Journal of Surgical Oncology·D B Frost
Jul 1, 1994·The British Journal of Surgery·C M LoJ Wong
Jan 1, 1997·The Journal of Thoracic and Cardiovascular Surgery·U PastorinoInternational Registry of Lung Metastases
Mar 1, 1997·The Annals of Thoracic Surgery·J H RobertP Goldstraw
Dec 9, 1997·Japanese Journal of Clinical Oncology·H NagahamaM Yoshimori
Feb 27, 2001·Journal of Surgical Oncology·T C MineoI Nofroni
Mar 30, 2001·The Journal of Thoracic and Cardiovascular Surgery·M T JaklitschD J Sugarbaker
Apr 27, 2002·Seminars in Thoracic and Cardiovascular Surgery·Nabil P Rizk, Robert J Downey
Oct 28, 2004·Gastroenterology·Brian I Carr
Aug 4, 2005·World Journal of Surgery·Jun NakajimaShinichi Takamoto

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