Prognostic factors for severity and mortality in patients infected with COVID-19: A systematic review

PloS One
Ariel IzcovichGabriel Rada

Abstract

The objective of our systematic review is to identify prognostic factors that may be used in decision-making related to the care of patients infected with COVID-19. We conducted highly sensitive searches in PubMed/MEDLINE, the Cochrane Central Register of Controlled Trials (CENTRAL) and Embase. The searches covered the period from the inception date of each database until April 28, 2020. No study design, publication status or language restriction were applied. We included studies that assessed patients with confirmed or suspected SARS-CoV-2 infectious disease and examined one or more prognostic factors for mortality or disease severity. Reviewers working in pairs independently screened studies for eligibility, extracted data and assessed the risk of bias. We performed meta-analyses and used GRADE to assess the certainty of the evidence for each prognostic factor and outcome. We included 207 studies and found high or moderate certainty that the following 49 variables provide valuable prognostic information on mortality and/or severe disease in patients with COVID-19 infectious disease: Demographic factors (age, male sex, smoking), patient history factors (comorbidities, cerebrovascular disease, chronic obstructive pulmonary dise...Continue Reading

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Methods Mentioned

BETA
X ray

Software Mentioned

R
Google Scholar
metafor package
PROGnosis RESearch Strategy ( PROGRESS )

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