PMID: 2119684Sep 1, 1990Paper

Prognostic factors in advanced epithelial ovarian cancer. (Gruppo Interregionale Cooperativo di Oncologia Ginecologica (GICOG))

British Journal of Cancer
S MarsoniG Favalli

Abstract

The data on 914 patients enrolled in four randomised trials in advanced ovarian cancer, consecutively conducted by the same cooperative group between 1978 and 1986, were analysed with the aims of: (1) determining the impact of selected prognostic variables on survival; (2) finding, from the interaction of favourable prognostic factors and treatment, an approximate estimate of the magnitude of the survival advantage associated with the use of platinum-based combination chemotherapy. The overall 3-year survival in this series of patients is twice that reported historically (22%; 95% CL 18.7-25.4). The proportional hazard regression model was used to perform the analysis on survival. Residual tumour size, age, FIGO stage and cell type were all independent determinants of survival. Differences in survival from the various prognostic groups were impressive with 5-year survival rates ranging from 7 to 62%. However, these differences were not qualitative (i.e. the kinetics of survival were similar for the best and the worst groups) suggesting that current prognostic factors are of little use for selecting 'biologically' different sub-populations. Platinum-based regimens were associated to an overall prolonged median survival, but this...Continue Reading

Citations

May 16, 2002·BJOG : an International Journal of Obstetrics and Gynaecology·J ByromS Tebby
Aug 21, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·William E WinterUNKNOWN Gynecologic Oncology Group Study
Oct 11, 2001·British Journal of Cancer·T G ClarkJ F Smyth
Mar 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Don S DizonDavid R Spriggs
Jan 1, 1997·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·A GadducciR Cristofani
Feb 1, 1995·Annals of Medicine·T Högberg
Apr 17, 2004·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·R E J HowellsR C Strange
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Jan 1, 1992·Acta Obstetricia Et Gynecologica Scandinavica. Supplement·K D Swenerton
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