Prognostic factors in children with PRES and hematologic diseases

Acta Neurologica Scandinavica
N TambascoA Verrotti

Abstract

Posterior reversible encephalopathy syndrome (PRES) is a clinical and radiological entity characterized by focal neurological signs, headache, confusion, and seizure, associated with transitory lesions in the posterior areas of the brain detectable with neuroimaging. Among children, one of the most common causes of PRES is cancer. In this review, we present the cases of 5 children developing PRES after stem cell transplantation for hematological disease and review all the cases reported in English literature to investigate outcomes and associated risk factors. One hundred and eleven cases were reported. Hypertension was very frequent (80%). Clinical features included seizures (80.1%), headache (44.1%), visual disturbance (26.1%), and mental change (48.6%). EEG was abnormal in 27 of 32 patients. MRI revealed characteristic lesions in all patients even in early stages. Abnormal MRI findings in late stages were associated with neurological sequelae. Nineteen patients died (17.1%) of which 2 of PRES. Among alive patients, 17 had neurological sequelae. Four cases of PRES relapse were described. Thus, all transplant recipients with symptoms consistent with PRES should be promptly recognized to avoid long-term complications or even de...Continue Reading

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Citations

Dec 5, 2017·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Katarzyna MusiołGrażyna Sobol-Milejska
Aug 11, 2017·Journal of Neurology, Neurosurgery, and Psychiatry·Bo GaoAlexander M McKinney
Jan 6, 2017·Journal of Neurology·Marlene Fischer, Erich Schmutzhard
Jun 22, 2018·Neural Regeneration Research·Adriana Octaviana Dulamea, Ioana Gabriela Lupescu
Feb 26, 2021·Case Reports in Neurological Medicine·Joseph Seemiller, Muhammad Taimur Malik
Nov 4, 2020·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Duccio Maria CordelliRiccardo Masetti
Oct 17, 2020·Journal of Pediatric Hematology/oncology·Özlem A BilirNamik Y Özbek

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