Prognostic factors in differentiated thyroid cancer--a 20-year surgical outcome study.

Langenbeck's Archives of Surgery
Aleksander KonturekPiotr Richter

Abstract

The aim of this study was to determine prognostic factors in patients operated on for well-differentiated thyroid cancer (WDTC). A retrospective cohort study of patients with WDTC treated at our institution between 1989 and 1991 (n = 97; mean age 52.3 years, 78 females, follow-up 124.6 ± 75.1 months) was made. Multivariate analysis was performed including: age, gender, size of primary tumor, location and number of foci in thyroid tissue, clinical stage, thyroid capsule infiltration, tumor histological type, extent of surgery, prognosis based on the AGES and MACIS scores, and tumor proliferative activity based on determination of proliferating cell nuclear antigen (PCNA) and Ki-67 expression in tumor tissue and nodal metastases. The multivariate analysis showed increased relative risk (RR) of death for: age above 60 years (7.39; p < 0.001), pTm (2.94; p = 0.002), pT3 (11.83; p < 0.001), and pN1 (4.11; p < 0.001). Total thyroidectomy decreased RR of death (0.39; p = 0.023) when compared to more limited resections. Moderate and high PCNA index was associated with 48.3% and 87.5% mortality, respectively, while Ki-67 index was associated with the highest mortality rate (76%) in the group of medium values. Despite good prognosis in W...Continue Reading

References

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Citations

Dec 1, 2014·Surgical Pathology Clinics·Guido Fadda, Esther Diana Rossi
Aug 29, 2014·European Journal of Endocrinology·Hoonsung ChoiBo Youn Cho
Jan 15, 2013·Medical Hypotheses·Nastaran Ranjbari, Fakher Rahim
May 20, 2015·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·J Hendrickson-RebizantK A Pathak
Nov 5, 2014·Thyroid : Official Journal of the American Thyroid Association·Stefano Christian LonderoChristian Godballe
Jul 31, 2014·Annals of Surgical Oncology·Wesley H GilesNancy L Cho
Mar 16, 2017·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Daniel Bräuner SkansingChristian Godballe
Apr 2, 2021·Scientific Reports·Federica VianelloCaterina Mian

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