Prognostic factors in esophageal squamous cell carcinoma patients treated with neoadjuvant chemoradiation therapy.

International Journal of Clinical Oncology
Hiroshi OkumuraShoji Natsugoe

Abstract

Definitive evaluation of surgical specimens obtained after neoadjuvant chemoradiation therapy (CRT) is important for assessing additional treatment or prognosis in patients with esophageal squamous cell carcinoma (ESCC). In this study, we examined the histological prognostic factors for ESCC patients treated with CRT and determined an appropriate strategy for their evaluation. The present study involved 38 consecutive ESCC patients who underwent CRT followed by curative operation. CRT consisted of 5-fluorouracil plus cisplatin and 40 Gy of radiation. We examined histological variables as follows: CRT effect on primary tumor (T-effect: T-effective/T-ineffective), tumor depth (pT), lymph node metastases (pN: pN0/N1), number of lymph node metastases (number-pN), lymphatic invasion, and venous invasion. Univariate and multivariate analyses were performed to examine the independent prognostic factors. Survivals and mode of recurrence were then evaluated according to the independent prognostic factors. In the univariate analyses, T-effect, pN, number-pN, lymphatic invasion, and venous invasion were found to be prognostic factors with p < 0.01, and pT was a factor with p < 0.05. In the multivariate analysis, pN and T-effect were indep...Continue Reading

References

Jan 13, 2000·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·D S Schrump, D M Nguyen
Aug 2, 2006·British Journal of Cancer·Y KitaT Aikou
Oct 31, 2006·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·S NatsugoeT Aikou
Nov 23, 2006·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Simon LawJohn Wong

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Citations

Aug 28, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Jhe-Cyuan GuoChih-Hung Hsu
Nov 7, 2015·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·H OkumuraS Natsugoe
Sep 2, 2020·Journal of Experimental & Clinical Cancer Research : CR·Xiaobin GuoZhihua Liu

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