PMID: 9448610Feb 4, 1998Paper

Prognostic factors in gastric cancer

The British Journal of Surgery
H AllgayerF W Schildberg

Abstract

Despite gastric cancer being common, its prognosis has not been improved significantly in recent years. Now, greater insight has been gained into the biological properties of tumour cells, how they become malignant and what mechanisms they may use to invade and metastasize. This involves tumour-associated protease systems, loss or mutation of adhesion molecules and changes in genetics. The view of gastric cancer is changing: it is not only a solid tumour but also exhibits a minimal residual disease component even in the early stages of disease. Such biological tumour characteristics may provide new prognostic factors and also potential new therapeutic options. This is an update of prognostic factors in gastric cancer, emphasizing new biological features, some of which have been investigated by this group over the past few years. Current results are discussed in the light of 212 references obtained from the Medline database from 1979 to 1997. There is high probability that some of the factors reviewed, such as c-erbB-2, individual course and phenotyping of disseminated tumour cells will become significant new prognostic variables. This is true also, to a lesser extent, of cathepsin D, matrix metalloproteinase 2 combined with act...Continue Reading

References

Nov 30, 1992·Biochemical and Biophysical Research Communications·H KuniyasuE Tahara
Apr 1, 1992·Journal of Surgical Oncology·M TateishiS Nagasaki
Jun 13, 1992·Lancet·I R Hart, A Saini
Oct 1, 1992·Current Opinion in Cell Biology·W T Chen
Jan 1, 1992·Virchows Archiv. A, Pathological Anatomy and Histopathology·H OkaS Hirano
Apr 1, 1992·International Journal of Cancer. Journal International Du Cancer·H M MartinF Silvestre
May 1, 1992·Clinical & Experimental Metastasis·M J Duffy
Jun 1, 1992·Seminars in Cell Biology·J BehrensW Birchmeier
Jan 21, 1992·International Journal of Cancer. Journal International Du Cancer·H E GabbertG Hommel
Sep 9, 1991·International Journal of Cancer. Journal International Du Cancer·H E GabbertG Hommel
Sep 1, 1991·Japanese Journal of Cancer Research : Gann·H KuniyasuD S Salomon
Jan 24, 1991·The New England Journal of Medicine·T J MossR C Seeger
Apr 1, 1991·The Journal of Cell Biology·U H FrixenW Birchmeier
Jan 1, 1990·Journal of Cancer Research and Clinical Oncology·E Tahara
Jun 1, 1990·Cell·E R Fearon, B Vogelstein
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·G SchlimokG Riethmüller
Aug 1, 1989·Japanese Journal of Cancer Research : Gann·K YoshidaE Tahara
Sep 1, 1989·World Journal of Surgery·G H KampschöerC J van de Velde
Feb 15, 1988·International Journal of Cancer. Journal International Du Cancer·W YasuiE Tahara
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C I Bargmann, R A Weinberg
Apr 6, 1988·Journal of the National Cancer Institute·P S SteegM E Sobel

❮ Previous
Next ❯

Citations

Feb 8, 2013·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Kyoung-Joo KwonSung-Ae Jung
Mar 2, 2011·Journal of Gastrointestinal Cancer·María SerenoManuel González Barón
Jun 3, 2000·The Surgical Clinics of North America·H J SteinJ R Siewert
Feb 28, 2003·International Journal of Radiation Oncology, Biology, Physics·Rebecca K S WongUNKNOWN Cancer Care Ontario Practice Guidelines Initiative Gastrointestinal Cancer Disease Site Group
Apr 16, 2002·The British Journal of Surgery·W YuH Y Chung
Sep 18, 2012·Journal of the National Cancer Institute·Hua FangYves A DeClerck
Feb 24, 1999·Inflammatory Bowel Diseases·P L Beck, D K Podolsky
Dec 4, 2008·Annals of Surgical Oncology·Chiung-Nien ChenKing-Jen Chang
Oct 22, 2011·International Journal of Molecular Sciences·Wei Zhang, Yingyan Yu
Jun 2, 2012·World Journal of Gastroenterology : WJG·Hai-Zhen DangShun-Chang Jiao
Jan 31, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Demao YaoPeng Hou
Jul 6, 2010·World Journal of Surgery·Andrew B C CrumleyDonald C McMillan
Oct 3, 2008·Journal of Cancer Research and Clinical Oncology·Shu-Qin JiaJia-Fu Ji
Jun 7, 2005·Expert Opinion on Therapeutic Targets·Xiu Feng Hu, Pei Xiang Xing
Jan 29, 2008·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S ScaringiS Msika
Nov 28, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Y P GongD J Gillett
Jan 15, 2005·Biochemical and Biophysical Research Communications·Dai ShidaHirokazu Nagawa
Aug 9, 2008·International Journal of Cancer. Journal International Du Cancer·Wan-Li ChengKwang-Huei Lin
Sep 4, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Qiong-Wen ZhangYu-Wei Zhao
Jun 28, 2016·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·P A van DamC Rolfo
Apr 18, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Heike Allgayer
Jan 15, 2015·Cancer Biology & Therapy·Satsuki MashikoNobuo Yaegashi
Sep 8, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Chiung-Nien ChenFon-Jou Hsieh
Dec 7, 2007·Arquivos De Gastroenterologia·Leonardo Landim FernandesJaques Waisberg
Dec 20, 2002·International Journal of Surgical Pathology·João Pinto-de-SousaAmadeu Pimenta
Sep 21, 2004·World Journal of Gastroenterology : WJG·Cheng-Wu ZhangDa-Jian Zhao
Nov 3, 2001·Genome Research·M XiongJ Zhao
Jun 10, 2009·European Journal of Gastroenterology & Hepatology·Ozgür IlhanBinnur Onal
Apr 14, 2017·Oncotarget·Siyuan ChenHong Guo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.