Prognostic factors in invasive squamous cell carcinoma of the penis: analysis of 196 patients treated at the Brazilian National Cancer Institute

The Journal of Urology
Antonio Augusto OrnellasAline Barros de Santos Schwindt

Abstract

We evaluated the role of primary tumor histopathological features for predicting regional metastasis and the prognosis in patients with penile squamous cell carcinoma. From April 1996 to January 2007, 202 consecutive patients with penile carcinoma underwent surgical treatment at our institution. Of these patients 196 were studied to identify prognostic factors. All histological specimens were examined by the same pathologist. We considered certain histological parameters, including histological grade, invasion depth, lymphovascular embolization, perineural infiltration, infiltration of the corpus cavernosum or spongiosum, urethral infiltration and koilocytosis. Variables significantly associated with regional metastasis on univariate analysis were stage stratification (p = 0.0338), histological grade (p = 0.0112), invasion depth (0.0114), lymphovascular embolization (p <0.0001), perineural infiltration (p = 0.0092), corpora cavernosa infiltration (p = 0.0005) and koilocytosis (p = 0.0013). In the multivariable model lymphovascular embolization and absent koilocytosis were independent risk factors for lymphatic metastasis (p = 0.001 and 0.009, respectively). We also found a better survival rate in patients with koilocytosis and ...Continue Reading

References

May 1, 1991·British Journal of Urology·A G MaicheM Karkinen
Oct 1, 1993·European Journal of Obstetrics, Gynecology, and Reproductive Biology·U HørdingJ Junge
Aug 1, 1997·British Journal of Urology·C F HeynsD J van Velden
Jan 14, 1998·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J C SoriaC Théodore
Mar 1, 1955·Cancer·W J STAUBITZO J OBERKIRCHER

❮ Previous
Next ❯

Citations

Jan 8, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G SonpavdeG Di Lorenzo
Apr 23, 2009·The American Journal of Surgical Pathology·Alcides ChauxAntonio L Cubilla
Nov 21, 2012·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Kimberly L BradyMarc D Brown
Nov 2, 2015·The Kaohsiung Journal of Medical Sciences·Jiun-Hung GengChao-Yuan Huang
May 31, 2012·Seminars in Diagnostic Pathology·Alcides Chaux, Antonio L Cubilla
Nov 18, 2011·The Journal of Urology·Adriano Augusto Peclat De PaulaMegmar Aparecida dos Santos Carneiro
Nov 3, 2011·The Urologic Clinics of North America·Simon Horenblas
Apr 19, 2011·Human Pathology·Daniele MinardiGiovanni Muzzonigro
Aug 19, 2010·Urology·Chris F HeynsHendrik van Poppel
Dec 1, 2009·Urologic Oncology·Boris SchlenkerEdwin Hungerhuber
Apr 2, 2014·Journal of the European Academy of Dermatology and Venereology : JEADV·U WollinaG Tchernev
Mar 10, 2015·BMC Clinical Pathology·Lara TerminiGustavo C Guimarães
Aug 15, 2014·Abdominal Imaging·Chong Hyun SuhAtul B Shinagare
Oct 9, 2016·The Urologic Clinics of North America·S Horenblas, S Minhas
Jan 11, 2013·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Paulo OrnellasFulvio Magni
Jan 11, 2013·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Lúcio Flávio Gonzaga-SilvaMarcos V A Lima
May 12, 2011·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Leandro KoifmanAntonio A Ornellas
Jan 3, 2019·Current Opinion in Urology·Yannic RaskinMaarten Albersen
May 23, 2013·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·M MistrangeloP Cassoni
Sep 23, 2014·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Eva Serup-HansenHanne Havsteen
Sep 12, 2014·The American Journal of Surgical Pathology·Mark J MentrikoskiHelen P Cathro
Aug 26, 2018·European Journal of Nuclear Medicine and Molecular Imaging·André SalazarMarcelo Mamede
Jun 20, 2020·World Journal of Gastroenterology : WJG·Preeti SharmaShanmugarajah Rajendra
Feb 4, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Laurent ZiniPierre I Karakiewicz
Dec 30, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Andrew FeberJohn D Kelly
Feb 13, 2021·Nature Reviews. Disease Primers·Anita ThomasMaarten Albersen
Jun 9, 2010·Archives of Pathology & Laboratory Medicine·Elsa F VelazquezUNKNOWN Members of the Cancer Committee, College of American Pathologists

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Cancer Incidence & Mortality

Cancer has emerged as a global concern due to its increase in incidence and mortality. Efforts are underway to evaluate and develop action plans to reduce the global burden of cancer. Currently, lung cancer, breast cancer and prostate cancer are the leading causes of cancer mortality. Here is the latest research on cancer incidence and mortality.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.