Prognostic factors in laryngeal carcinoma: the role of apoptosis, p53, proliferation (Ki-67) and angiogenesis

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
Heikki TeppoOlli-Pekka Alho

Abstract

Even though the roles of different known or suggested prognostic factors in laryngeal cancer have been studied in detail, clinical stage at time of diagnosis and anatomic subsite of the tumour remain the only practical predictors of clinical outcome and offer the only guidelines in the planning of treatment. In this study, the relative roles of known demographic and clinical prognostic factors, in addition to four histopathological factors, were evaluated in a sample of 100 laryngeal carcinoma patients with multivariate analysis using the Cox regression model. In addition to advanced stage (stage III-IV) (relative hazard of death (HR) 8.9, p=0.01) and supraglottic disease (HR 5.6, p=0.02), high apoptotic index (HR 11.1, p=0.05) was significantly associated with poor survival. Cell proliferation, p53 and angiogenesis did not significantly affect the prognosis. In the future, high degree of apoptosis could be used to identify patients with poor prognosis in laryngeal cancer.

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Citations

Jul 21, 2005·Journal of the National Cancer Institute·Panayiotis A KyzasJohn P A Ioannidis
Oct 2, 2007·European Journal of Nuclear Medicine and Molecular Imaging·David LooseChristophe Van de Wiele
Jun 4, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Federico Maria GioacchiniMassimo Re
Jan 27, 2015·Brazilian Journal of Otorhinolaryngology·Christiana Vargas RibeiroJosé de Souza Andrade Filho
Jan 28, 2012·The Annals of Otology, Rhinology, and Laryngology·Bin ShenShang Gao
Nov 13, 2013·Cancers·Frédéric L W V J Schaper, Chris P Reutelingsperger

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