Prognostic factors in melanoma patients with tumor-negative sentinel lymph nodes

Surgery
Michael E EggerCharles R Scoggins

Abstract

Sentinel lymph node (SLN) biopsy for melanoma results in accurate nodal staging, which guides treatment decisions. Patients with a negative SLN biopsy in general have a favorable prognosis, but certain subsets are at increased risk for recurrence and death. This study aimed to identify risk factors predictive of prognosis in patients with a tumor-negative SLN biopsy for cutaneous melanoma. In this post-hoc analysis of data from a multicenter prospective randomized trial, clinicopathologic data of patients with cutaneous melanoma ≥1.0 mm Breslow thickness and tumor-negative SLN were analyzed. Disease-free survival, overall survival (OS), and local and in-transit recurrence-free survival were compared by Kaplan-Meier analysis. Risk factors for worse survival were identified with Cox proportional hazard models. This analysis included 1,998 patients with tumor-negative SLN with a median follow-up of 70 months. Ulceration, Breslow thickness, nonextremity tumor location, and age ≥45 years were independent risk factors for worse disease-free survival and OS. Breslow thickness and ulceration were the only factors on multivariate analysis that predicted local and in-transit recurrence-free survival. Estimated 5-year OS rates ranged from...Continue Reading

References

Apr 1, 1992·Archives of Surgery·D L MortonA J Cochran
Mar 3, 2004·Annals of Surgical Oncology·Celia ChaoKelly M McMasters
Mar 12, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·John M KirkwoodUNKNOWN Eastern Cooperative Oncology Group
Jun 29, 2004·Journal of Surgical Oncology·Kelly M McMastersUNKNOWN Sunbelt Melanoma Trial
May 12, 2005·Annals of Surgical Oncology·Vivian S K YeeRoger F Uren
Jun 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles R ScogginsKelly M McMasters
Mar 3, 2007·Annals of Surgical Oncology·Theresa G ZogakisDonald L Morton
Jun 26, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M MandalàC Tondini
Nov 18, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles M BalchVernon K Sondak
Dec 8, 2009·Annals of Surgical Oncology·Charles R ScogginsKelly M McMasters
Apr 10, 2010·Annals of Surgical Oncology·Seng-jaw SoongUNKNOWN AJCC Melanoma Task Force
Apr 27, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·John F ThompsonVernon K Sondak
Oct 16, 2012·Annals of Surgical Oncology·Michael E EggerCharles R Scoggins
Feb 14, 2014·The New England Journal of Medicine·Donald L MortonUNKNOWN MSLT Group

❮ Previous
Next ❯

Citations

Nov 28, 2018·Journal of Surgical Oncology·Minyoung KwakGeorgia M Beasley
May 31, 2020·Cancer Treatment Reviews·Tara D BaetzTeresa M Petrella
Jul 3, 2021·Nutrients·Harriet Johansson On Behalf Of The Italian Melanoma Intergroup Imi
Sep 14, 2021·Frontiers in Cell and Developmental Biology·Han ZhaoLan Gong

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.