PMID: 12198211Aug 29, 2002Paper

Prognostic factors in mesangioproliferative glomerulonephritis

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Bjørn Egil VikseBjarne M Iversen

Abstract

The aim of our study was to examine patients with mesangioproliferative glomerulonephritis (MPGN), with or without glomerular IgA deposits, and to analyse the effect of different clinical and histopathological variables at the time of biopsy on progression to end-stage renal failure (ESRF) and death. We retrospectively examined 273 patients who got this diagnosis in Norway from April 1988 to December 1990 after a renal biopsy. All patients were followed for a median duration of 34.8 months (0.8-68 months). The mean age at the time of biopsy was 40+/-17 years (range 1.1-79 years). Glomerular IgA deposits were present in 45% of the patients; IgA deposits did not affect prognosis. Three years after the time of biopsy, 7% had developed ESRF (chronic dialysis treatment or kidney transplantation) and 8% had died. By Kaplan-Meier analyses, the following clinical variables indicated progression to ESRF: increased serum creatinine, proteinuria > or =1 g/24 h, systolic blood pressure (BP) > or =160 mmHg, diastolic BP > or =90 mmHg, serum albumin <35 g/l, presence of urinary granular casts and age > or =60 years. Morphological variables indicating progression to ESRF were presence of focal mesangial sclerosis, focal glomerular crescents o...Continue Reading

Citations

Nov 18, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Chiao-Yin SunMai-Szu Wu
Apr 4, 2012·Journal of Hypertension·Michael Hultström
Feb 26, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Silvestre García-de la PuenteBeatriz de Leon Bojorge
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