Abstract
A consensus has not yet been reached regarding the abilities of gender, age, tumor size, tumor location, histologic subtypes, and surgery in the prediction of survival in osteosarcoma. We aimed to disclose their prognostic significance by conducting a meta-analysis of all the published data from the last decade. Electronic database searches were conducted in PubMed, Embase, and Web of Science for relevant articles published within the last ten years. The pooled hazard ratio (HR) and corresponding 95% confidence interval (CI) were obtained to evaluate the prognostic values of the target factors. A total of 18,126 patients from 40 studies were eventually included. Results indicated that gender (male vs. female: 1.21, 95% CI, 1.11-1.32; female vs. male: 0.85, 95% CI, 0.75-0.98), age (12-20 vs. ≤12: 1.37, 95% CI, 1.13-1.65; ≥20 vs. <20: 1.29, 95% CI, 1.08-1.55; ≥40 vs. <40: 1.63, 95% CI, 1.21-2.20; ≥50 vs. <25: 2.60, 95% CI, 1.92-3.53; ≥60 vs. <60: 1.11, 95% CI, 1.06-1.18), tumor location (non-extremities vs. extremities: 2.10, 95% CI, 1.76-2.51; proximal vs. distal femur: 3.68, 95% CI: 1.51-8.96; proximal vs. distal humerus: 3.15, 95% CI: 1.53-6.49), tumor size (≥5 vs. <5: 1.42, 95% CI, 1.09-1.86; >8 vs. ≤8: 1.55, 95% CI, 1.07-2.2...Continue Reading
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