Prognostic factors in patients with advanced pancreatic adenocarcinoma treated with intra-arterial chemotherapy

Pancreas
Andrea MambriniM Cantore

Abstract

The aim of this study is to identify the prognostic factors of a large group of patients with pancreatic cancer who underwent the same regimen of intra-arterial chemotherapy. 5-fluorouracil (1000 mg/m2), leucovorin (100 mg/m2), epirubicin (60 mg/m2), and carboplatin (300 mg/m2) were administered every 3 weeks into celiac axis (FLEC regimen). Kaplan-Meyer survival curve for univariate analysis and Cox regression model for multivariate one were used to determine factors predictive of survival. Data of 211 patients with advanced pancreatic cancer who underwent FLEC regimen were analyzed. Eighty-nine had locally advanced disease, and 112 had distant metastases. Median overall survival was 9.2 months. In both univariate and multivariate analyses, pain reduction after treatment (< or =30% of baseline level vs >30%; overall survival, 7.6 vs 11.5 months), stage of disease (III vs IV; overall survival, 10.5 vs 6.6 months), and number of administered cycles (< or =3 vs >3; overall survival, 5.9 vs 12.3 months) were significant and independent predictors of survival. Pain reduction, stage of disease, and number of administered cycles are independent prognostic factors of overall survival in a multivariate analysis of patients with advance...Continue Reading

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Citations

Nov 4, 2011·American Journal of Epidemiology·Zhihong GongPaige M Bracci
Apr 19, 2011·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Jun SatoYoshimasa Kitagawa
Oct 3, 2015·Tumori·Jacopo GiulianiAndrea Bonetti
Feb 5, 2019·Oncotarget·Marie-Andrée ForgetChantale Bernatchez
Jun 15, 2019·Journal of Medical Engineering & Technology·Santosh Nagnath RandiveAmol D Rahulkar

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