Prognostic factors in patients with gastric adenocarcinoma using competing-risk analysis: a study of cases in the SEER database

Scandinavian Journal of Gastroenterology
Xu ZhangJun Lyu

Abstract

Background: Accurate prognostic factors for gastric adenocarcinoma are still lacking in clinical practice, which contributes to inappropriate treatment. Applying the widely used Cox-proportional hazards model to describe survival trends and identify prognostic factors has limitations that result in a risk of bias. A competing-risk model was therefore adopted in this study to identify the significant prognostic factors and evaluate the cumulative incidence of cause-specific death for gastric adenocarcinoma, which can be used to guide clinical treatments. Methods: All of the cases analyzed in this study were extracted from the SEER (Surveillance, Epidemiology, and End Results) database. Using the competing risk approach, we calculated the cumulative incidence function (CIF) for cause-specific death and death from other causes at each time point. The Fine and Gray's proportional subdistribution hazard model was then applied in the univariate analysis and multivariate analysis to test the differences in CIF between different groups and obtain independent prognostic factors. Results: The univariate analysis showed that patients with characteristics of advanced pathology grade, lymph node involvement, and metastasis, were at risk of ...Continue Reading

References

Apr 30, 2002·Seminars in Radiation Oncology·Leonard L Gunderson
Oct 26, 2005·Chinese Journal of Digestive Diseases·Wei Cheng YouKai Feng Pan
Apr 15, 2006·Annals of Surgical Oncology·Marcelo Leite Vieira CostaAndré Luis Montagnini
Jan 27, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Haesook T Kim
Jun 15, 2007·Bone Marrow Transplantation·L ScruccaF Aversa
Jul 27, 2007·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·P Khosravi ShahiG Pérez Manga
Jan 8, 2009·Journal of Experimental & Clinical Cancer Research : CR·Gustavo Arruda VianiEduardo Jose Stefano
Apr 28, 2009·Journal of Experimental & Clinical Cancer Research : CR·Ji-wei YuBo-jian Jiang
Jun 6, 2009·American Journal of Epidemiology·Bryan LauStephen J Gange
Nov 6, 2009·British Journal of Cancer·M YaghoobiS A Narod
Jan 1, 2009·Oncology·Ferdinando De VitaMichele Orditura
Jul 9, 2010·CA: a Cancer Journal for Clinicians·Ahmedin JemalElizabeth Ward
Dec 14, 2011·Journal of the National Cancer Institute·Vincent James CoglianoChristopher P Wild
Apr 14, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jian-Song RenFarhad Islami
Jun 26, 2012·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Atsushi NashimotoMichio Kaminishi
Jan 8, 2013·World Journal of Gastrointestinal Endoscopy·René Lambert
Aug 24, 2013·The Oncologist·Noman AshrafRichard Kim
Mar 19, 2014·Medical Care·Anne-Michelle NooneJoan L Warren
Jun 28, 2014·International Journal of Radiation Oncology, Biology, Physics·Ruben CarmonaLoren K Mell
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray
Jan 30, 2015·Annals of Surgical Oncology·Kaitlyn J KellyVivian E Strong
Feb 18, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ruben CarmonaLoren K Mell
May 28, 2016·The Journal of Surgical Research·A AhmadP Somasundar
Apr 28, 2017·Annals of Cardiothoracic Surgery·Thomas W RiceEugene H Blackstone
Aug 19, 2017·Journal of the American College of Cardiology·Babak B NaviLisa M DeAngelis
Sep 16, 2017·Statistics in Medicine·Peter C Austin, Jason P Fine
Nov 12, 2017·Journal of Surgical Oncology·Emmanuel GabrielMoshim Kukar

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