Prognostic factors in patients with idiopathic portal hypertension: Two Japanese nationwide epidemiological surveys in 1999 and 2005

Hepatology Research : the Official Journal of the Japan Society of Hepatology
Yoko MuraiYoshio Hirota

Abstract

To investigate factors affecting disease prognosis among patients with idiopathic portal hypertension (IPH). Two Japanese nationwide epidemiological surveys on IPH were conducted in 1999 and 2005. Analyzing data from each cross-sectional survey separately, we examined the consistent prognostic factors detected from each analysis and assessed the effect of treatments for varices on IPH prognosis. Outcome was the disease condition at last observation compared with that at diagnosis, categorized into two levels (recovered/improved and unchanged/aggravated/deceased). To evaluate the association with each characteristic, we calculated adjusted odds ratio (OR) and 95% confidence interval (CI) using a binary model for logistic regression. Among 160 patients with IPH in 1999 and 85 in 2005, 10% had aggravated disease at a mean of 6-7 years after the diagnosis. Statistically significant ORs were observed for two factors: esophageal varices, especially of F(2-3) stage, at diagnosis (OR = 6.83, 95% CI = 2.10-22.1 in 1999; OR = 10.7, 95% CI = 1.08-105 in 2005) ameliorated IPH; and hepatic encephalopathy at diagnosis (OR = 0.19, 95% CI = 0.03-1.04 in 1999; crude OR = 0.05, 95% CI = 0.01-0.60 in 2005 using a proportional odds model) worsened...Continue Reading

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Citations

Nov 22, 2018·Journal of Gastroenterology and Hepatology·Yongliang SunZhiying Yang
Apr 5, 2019·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Satoko OhfujiYosikazu Nakamura
Jan 7, 2017·Hepatology Research : the Official Journal of the Japan Society of Hepatology·UNKNOWN Working Subgroup for Clinical Practice Guideline for Aberrant Portal Hemodynamics*,**
Feb 22, 2018·Hepatology International·Rajeev Khanna, Shiv Kumar Sarin

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