Abstract
Nuclear texture reflects the overall structures of the chromatin organization. We recently reported the principles and prognostic importance of image analysis of nuclei from metastatic prostate cancer. Immunohistochemical up regulation of the adhesion molecule sialyl Lewis(x) is also reported to be a prognostic parameter. Presently we analyzed statistically the prognostic impact of these 2 new parameters compared to well-known clinical parameters in metastatic prostate cancer. Prognostic factors, such as sedimentation rate, alkaline and acid phosphatases, hemoglobin, testosterone, performance status, pain due to metastasis, T category, histological grade and patient age, were included in a multivariate Cox proportional hazards regression analysis based on 262 patients from the Scandinavian Prostatic Cancer Group Study-2. Extent of bone lesions, deoxyribonucleic acid ploidy, texture analysis and sialyl Lewis(x) molecules based on subsets of these 262 patients were also analyzed in the same multivariate model. This test identified chromatin texture as the most important factor (p < 0.001), followed by reaction of the oligosaccharide sialyl Lewis(x) (p < 0.01). Among the routine clinical and laboratory data, sedimentation rate, al...Continue Reading
References
Dec 1, 1977·Southern Medical Journal·W P JordanD P Byar
Jan 1, 1977·British Journal of Cancer·R PetoP G Smith
Jul 2, 1992·The New England Journal of Medicine·M MiyakeS Hakomori
Jan 1, 1992·The Prostate. Supplement·O Dalesio
Feb 6, 1991·JAMA : the Journal of the American Medical Association·G W ChodakJ A Smith
Aug 1, 1991·The Journal of Urology·D S ErnstP M Venner
Jun 15, 1990·Cancer·P F MuldersF M Debruyne
Mar 1, 1990·Cancer·D E Merkel, W L McGuire
Apr 1, 1989·The Journal of Urology·H J de VoogtM de Pauw
May 1, 1989·The Journal of Urology·S IshikawaB Todd
Jan 1, 1989·Advances in Cancer Research·S Hakomori
Nov 1, 1986·The Journal of Urology·D HickeyM S Soloway
Jan 1, 1988·The Prostate·A Eriksson, K Carlström
Jan 1, 1988·Cancer·M S SolowayM Moinuddin
Apr 1, 1984·European Journal of Cancer & Clinical Oncology·M E HarperK Griffiths
Nov 15, 1984·The New England Journal of Medicine·UNKNOWN Leuprolide Study Group
Sep 1, 1981·Urology·M GolimbuY Shulman
Jan 28, 1994·Cell·T A Springer
Apr 1, 1994·The Journal of Cell Biology·J GarriguesI Hellström
Aug 2, 1994·Proceedings of the National Academy of Sciences of the United States of America·A Varki
Jul 1, 1994·The Journal of Pathology·R van VelthovenR Kiss
May 1, 1995·British Journal of Cancer·T JørgensenH E Danielsen
Mar 19, 1994·BMJ : British Medical Journal·D P Dearnaley
Dec 1, 1993·Cancer·L DeligdischJ Gil
Jan 1, 1993·European Urology·T VisakorpiJ Isola
Jan 1, 1993·European Urology·T JørgensenL H Jørgensen
Aug 15, 1993·Cancer·H MatzkinG T Kennealey
Aug 15, 1993·Cancer·D D KomitowskiC P Janson
Aug 1, 1993·Glycobiology·T Muramatsu
Feb 1, 1993·Cancer·L Denis
Apr 1, 1993·Glycobiology·A Varki
Jan 1, 1995·European Urology·T JørgensenK J Tveter
Jul 1, 1996·Cytometry·K YogesanH E Danielsen
Jul 1, 1996·Cytometry·T JørgensenH E Danielsen
Citations
Apr 23, 2002·The Prostate·Hiroyoshi SuzukiHaruo Ito
Aug 6, 2002·European Urology·Theo de ReijkeUNKNOWN Anandron /Nilutamide Study Group
Apr 17, 2012·Asian Journal of Andrology·Jian HeShi-Suo Du
Sep 17, 2013·Asian Journal of Andrology·Cheng YangJian He
Jan 30, 1999·Radiographics : a Review Publication of the Radiological Society of North America, Inc·C A LawtonD A Kuban
Oct 2, 2009·Future Oncology·Takashi ImamotoTomohiko Ichikawa
Apr 12, 2011·Folia Histochemica Et Cytobiologica·M N KhabazR W Stoddart
Mar 29, 2008·Urology·Chung-Hsin ChenYeong-Shiau Pu
Apr 24, 2008·International Journal of Urology : Official Journal of the Japanese Urological Association·Takashi ImamotoTomohiko Ichikawa
Feb 18, 2005·European Urology·Takashi ImamotoTomohiko Ichikawa
Nov 28, 2006·European Urology·Jan LehmannMichael Stöckle
Aug 15, 2014·PloS One·Chien-Hua ChenHong-Chiang Chang
May 29, 2016·Urologic Oncology·Kunj R ShethVitaly Margulis
Nov 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eckart LaackDieter Kurt Hossfeld
May 2, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Norihiko TsuchiyaTomonori Habuchi
Sep 22, 2007·Cancer·Michael A CarducciUNKNOWN Atrasentan Phase III Study Group Institutions
Dec 24, 2002·Prostate Cancer and Prostatic Diseases·H NakamachiH Ito
Apr 22, 2009·Scandinavian Journal of Urology and Nephrology·Arto MikkolaUNKNOWN Finnprostate Group
Oct 6, 2020·Indian Journal of Surgical Oncology·Kouitcheu RomualdVarlet Guy
Aug 4, 2004·Cancer Research·Charles J DimitroffJeffery L Kutok