Prognostic factors in patients with methanol poisoning

Journal of Toxicology. Clinical Toxicology
J J LiuS N Kales

Abstract

To identify prognostic factors in methanol poisoning and determine the effect of medical interventions on clinical outcome. Retrospective review of all patients treated for methanol poisoning from 1982 through 1992 at The Toronto Hospital. Presenting history, physical examination, results of laboratory tests, medical interventions, and final outcomes after hemodialysis were abstracted. Of 50 patients treated for methanol poisoning, 18 (36%) died, 32 (64%) survived. Seven of the 32 survivors sustained visual sequelae (22%), the remaining 25 (78%) recovered completely. Patients presenting with coma or seizure had 84% (16/19) mortality compared to 6% (2/31) in those without (p < 0.001). Initial arterial pH < 7 was also associated with significantly higher mortality (17/19, 89% vs 1/31, 3%, p < 0.001). There were no differences in time from presentation to dialysis between survivors and fatalities (8.4 +/- 3.6 vs 7.6 +/- 3.5 hours, p = 0.47). The deceased patients had higher mean methanol concentration than the survivors (83 +/- 53 vs 41 +/- 25 mmol/L, p = 0.004). Subgroup analysis of 19 patients presenting with visual symptoms who survived showed prolonged acidosis (5.4 +/- 2.3 vs 3.0 +/- 2.1 hours, p = 0.06) in those with persist...Continue Reading

References

Nov 17, 1975·Biochemical and Biophysical Research Communications·P Nicholls
Feb 1, 1979·Australian and New Zealand Journal of Medicine·S NaraqiJ S Sairere
Mar 1, 1989·Human Toxicology·P MahieuR Lauwerys
Nov 1, 1989·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·T J AndersonW J Becker
Sep 1, 1988·Medical Toxicology and Adverse Drug Experience·D JacobsenK E McMartin
Feb 1, 1986·Annals of Internal Medicine·J D OsterlohC E Becker
Jul 1, 1968·Archives of Environmental Health·R L KaneS Cataland
Jan 1, 1983·The Journal of Emergency Medicine·C E Becker
Jan 1, 1983·Acta Medica Scandinavica·D JacobsenO M Sejersted
Oct 1, 1982·Critical Reviews in Toxicology·O Röe
Jan 1, 1983·Acta Medica Scandinavica·O M SejerstedH Jansen
Jan 1, 1982·Acta Medica Scandinavica·D JacobsenJ Ostborg
Jan 1, 1982·Acta Medica Scandinavica·D JacobsenS Halvorsen
Mar 1, 1980·The American Journal of Medicine·K E McMartinT R Tephly
Feb 1, 1997·Japanese Journal of Clinical Oncology·J M LiuJ Whang-Peng
Jan 1, 1997·Journal of Toxicology. Clinical Toxicology·D Jacobsen, K E McMartin

❮ Previous
Next ❯

Citations

Feb 13, 2007·Neuroradiology·S SefidbakhtS A Nabavizadeh
Nov 30, 2006·Cell Biology and Toxicology·N Jeya ParthasarathyR Sheela Devi
Mar 31, 2010·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Adeline Su-Yin NgoKent R Olson
Feb 22, 2011·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Hossein Sanaei-ZadehShahin Shadnia
Aug 5, 2003·The American Journal of Emergency Medicine·Mark B Mycyk, Steven E Aks
May 15, 2003·The Journal of Emergency Medicine·Karen A LushineJoel S Holger
May 16, 2002·Clinical Transplantation·A López-NavidadM A Frutos
Nov 8, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·George KanDavid Joyce
Jan 11, 2000·Critical Care Medicine·T E Albertson
Dec 29, 2000·Current Opinion in Nephrology and Hypertension·S Abramson, A K Singh
Jan 11, 2003·American Journal of Therapeutics·Mark B Mycyk, Jerrold B Leikin
Oct 24, 2002·European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine·R B BruyndonckxH H Delooz
Feb 23, 2013·Emergency Medicine International·Lorri BeattyPeter Zed
Feb 24, 2001·Intensive Care Medicine·P HantsonP Mahieu
Jan 1, 2005·Intensive Care Medicine·Bruno MégarbaneFrédéric J Baud
Nov 19, 2011·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Carolyn V CoulterStephen B Duffull
Mar 17, 2007·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·R PaasmaD Jacobsen
Oct 28, 2014·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Sergey ZakharovKnut Erik Hovda
Mar 17, 1999·Journal of Toxicology. Clinical Toxicology·J J LiuN C Mann
Sep 21, 2012·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Raido PaasmaDag Jacobsen
Sep 15, 2015·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Sergey ZakharovKnut Erik Hovda
Nov 18, 2008·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Erik A Wallace, Adam S Green
Mar 5, 2011·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Hossein Sanaei-ZadehShahin Shadnia
Jun 26, 2015·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Sergey ZakharovKnut Erik Hovda
Sep 13, 2007·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Nozha BrahmiMouldi Amamou
Jan 22, 2010·The American Journal of the Medical Sciences·Divakar Jammalamadaka, Sina Raissi
Jan 24, 2012·Toxicology Letters·Olivier DésyPedro O de Campos-Lima
Apr 16, 2016·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Ann Arens, Craig Smollin
Jul 13, 2004·Basic & Clinical Pharmacology & Toxicology·Jaroslaw DudkaElzbieta Korobowicz
Jan 26, 2016·Basic & Clinical Pharmacology & Toxicology·Sergey ZakharovDaniela Pelclova
Oct 23, 2008·Translational Research : the Journal of Laboratory and Clinical Medicine·Jai Moo ShinJeffrey A Kraut
Jul 10, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Olivier DésyPedro O de Campos-Lima
Oct 3, 2008·Human & Experimental Toxicology·K E Hovda, D Jacobsen
Apr 27, 2005·Human & Experimental Toxicology·P HantsonP Wallemacq
Feb 18, 2006·Journal of Occupational Health·Narayanaperumal J ParthasarathyRathinasamy S Devi
Jul 16, 2005·Journal of Internal Medicine·K E HovdaD Jacobsen
Oct 7, 2005·Journal of Applied Toxicology : JAT·Jaroslaw DudkaElzbieta Korobowicz
Oct 30, 2008·Journal of Immunotoxicology·N Jeya ParthasarathyR Sheela Devi
Jul 7, 2007·Journal of Pineal Research·Zehra KurcerErcument Olmez
Jun 7, 2019·BMC Nephrology·Shu-Ting ChangTzung-Hai Yen
Jan 1, 2002·Hemodialysis International·Charles T SpaldingAntonios H Tzamaloukas
Jul 20, 2007·CJEM·William R Henderson, Jeffrey Brubacher
Sep 10, 2002·Journal of Toxicology. Clinical Toxicology·Donald G BarcelouxUNKNOWN American Academy of Clinical Toxicology Ad Hoc Committee on the Treatment Guidelines for Methanol Poisoning
Aug 17, 2019·Annals of Intensive Care·Boris JungUNKNOWN Société Française de Médecine d’Urgence (SFMU)

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