Prognostic factors in patients with node-negative gastric carcinoma: a comparison with node-positive gastric carcinoma

World Journal of Gastroenterology : WJG
Dong Yi KimShin Kon Kim

Abstract

To identify the clinicopathological characteristics of lymph node-negative gastric carcinoma, and also to evaluate outcome indicators in the lymph node-negative patients. Of 2848 gastric carcinoma patients, 1524 (53.5%) were lymph node-negative. A statistical analysis was performed using the Cox model to estimate outcome indicators. There was a significant difference in the recurrence rate between lymph node-negative and lymph node-positive patients (14.4% vs 41.0%, P<0.001). The 5-year survival rate was significantly lower in lymph node-positive than in lymph node-negative patients (31.1% vs 77.4%, P<0.001). Univariate analysis revealed that the following factors influenced the 5-year survival rate: patient age, tumor size, depth of invasion, tumor location, operative type, and tumor stage at initial diagnosis. The Cox proportional hazard regression model revealed that tumor size, serosal invasion, and curability were independent, statistically significant, prognostic indicators of lymph node-negative gastric carcinoma. Lymph node-negative patients have a favorable outcome attributable to high curability, but the patients with relatively large tumors and serosal invasion have a poor prognosis. Curability is one of the most rel...Continue Reading

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Citations

May 13, 2010·Journal of Surgical Oncology·Hiroaki SaitoMasahide Ikeguchi
Jun 22, 2010·Annals of Surgery·Gian Luca BaiocchiGiovanni De Manzoni
Oct 19, 2016·Journal of Gastric Cancer·Eun Woo LeeHo-Seok Koo
Apr 11, 2012·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Xiaowen LiuYanong Wang
Jul 19, 2008·World Journal of Gastroenterology : WJG·Chang-Ming HuangJian-Wei Xie
Jul 31, 2008·World Journal of Gastroenterology : WJG·Chang-Ming HuangJian-Wei Xie
May 11, 2011·World Journal of Surgical Oncology·Ramakrishnan A SeshadriRama Ranganathan
Jul 3, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Yanming ZhouYumin Li
Dec 24, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lei HuangMichael T Spiotto
Mar 24, 2021·Annals of Surgical Oncology·Derek J ErstadNaruhiko Ikoma

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