PMID: 11343930May 10, 2001Paper

Prognostic factors in patients with resected pathologic (p-) T1-2N1M0 non-small cell lung cancer (NSCLC)

European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
F TanakaH Wada

Abstract

To clarify prognostic factors in resected pathologic (p-) T1-2N1M0 non-small cell lung cancer (NSCLC). A total of 95 consecutive patients who underwent complete tumor resection and mediastinal dissection for pT1-2N1M0 NSCLC between 1976 and 1997 were retrospectively reviewed. p53 status and proliferative activity were evaluated immunohistochemically. The extent of N1 stations and p53 status proved to be significant prognostic factors. The 5-year survival rate for tumor without hilar node (#10) involvement was 66%, significantly higher than that for tumor with #10 involvement (39%, P<0.01). The 5-year survival rate for tumor with aberrant p53 expression was 37%, significantly lower than that for tumor without aberrant p53 expression (74%, P<0.01). There proved to be no significant difference in the prognosis between pT1 disease and pT2 disease; the 5-year survival rates for pT1 and pT2 diseases were 62 and 56%, respectively. Age, gender, performance status, grade of tumor differentiation, histological type, or proliferative activity were not significant factors. Multivariate analysis of prognostic factors using Cox's proportional hazard model confirmed these results. Involvement of the hilar node and aberrant p53 expression were...Continue Reading

References

Sep 1, 1992·The Annals of Thoracic Surgery·N MartiniR J Ginsberg
Aug 21, 1992·Cell·B Vogelstein, K W Kinzler
Apr 2, 1987·Nature·R BravoH Macdonald-Bravo
Dec 15, 1993·Journal of the National Cancer Institute·T MitsudomiT Shirakusa
May 1, 1997·The Annals of Thoracic Surgery·E van VelzenJ M van den Bosch
Oct 7, 1998·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·F TanakaH Wada
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F TanakaH Wada
Aug 5, 2000·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·F TanakaH Wada

❮ Previous
Next ❯

Citations

Jul 24, 2007·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Ryuta FukaiHideaki Miyamoto
Oct 26, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Johannes M A DanielsJohan C van Mourik
Nov 23, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Caroline RiveraJacques Jougon
Nov 17, 2009·World Journal of Surgical Oncology·Dragan SuboticMaja Ercegovac
Sep 18, 2012·Multidisciplinary Respiratory Medicine·Nicola CiancioGiuseppe U Di Maria
May 20, 2004·Annals of Surgical Oncology·Fumihiro TanakaHiromi Wada
Jan 30, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C MacdonaldJ Mansi
Dec 20, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Katsunari MatsuokaNoriyuki Misaki
Mar 28, 2009·The Annals of Thoracic Surgery·Adalet DemirSeyit Ibrahim Dincer
Jun 26, 2007·The Annals of Thoracic Surgery·Robert J Cerfolio, Ayesha S Bryant
Apr 6, 2004·The Annals of Thoracic Surgery·Omar A KhanJohn P Duffy
Jul 13, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Federico ReaFrancesco Sartori
Aug 29, 2006·The Journal of Thoracic and Cardiovascular Surgery·Toshio FujimotoPeter C Pairolero
Jul 19, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Juan P WisniveskyMichael C Iannuzzi
Mar 21, 2002·Clinics in Chest Medicine·Lynn T Tanoue, Ronald B Ponn
Sep 20, 2019·General Thoracic and Cardiovascular Surgery·Masaya TamuraHirofumi Takemura
Jan 18, 2008·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Pedro Augusto Reck Dos SantosJosé Antonio Lopes de Figueiredo Pinto
Dec 1, 2020·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Zihuai WangLunxu Liu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.