Prognostic factors in previously treated non-small cell lung cancer patients with and without a positive response to the subsequent treatment with gefitinib

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Hiroshi WatayaYukito Ichinose

Abstract

Gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, has been reported to have a certain anti-tumor effect in previously treated patients with non-small cell lung cancer (NSCLC). However, the prognostic factors in those patients with and without a positive response to gefitinib treatment remain unclear. A retrospective chart review was performed in 131 advanced NSCLC patients who received 250 mg of gefitinib as either a second-line or even later stage treatment from July 2002 to December 2005. The clinical factors including age, gender, performance status (PS), stage, histology, the number of prior types of chemotherapy, and the response to first-line chemotherapy were analyzed. One and 38 patients experienced a complete and partial response, respectively, to gefitinib treatment with an overall response rate of 30%. The median survival time (MST) of all patients receiving gefitinib treatment was 10 months while the MST was 28 months in the 39 gefitinib responders and 6 months in the 92 non-responders. Among the 39 gefitinib responders, the predominant prognostic factor was found to be the effectiveness of the first-line chemotherapy. The MST of the 20 patients with a response to the first-line chemotherapy ...Continue Reading

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Citations

Aug 6, 2011·Japanese Journal of Clinical Oncology·Atsushi OsoegawaYukito Ichinose
Aug 9, 2015·Clinical Oncology : a Journal of the Royal College of Radiologists·P K JulkaN Manoharan
Apr 1, 2014·Revue des maladies respiratoires·F Chermiti Ben AbdallahA Ben Kheder
Jul 18, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Ali InalAbdurrahman Isikdogan
Feb 12, 2010·Current Opinion in Oncology

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