PMID: 22555027May 5, 2012Paper

Prognostic factors in renal cell carcinoma: analysis of 227 patients treated at the Brazilian National Cancer Institute

International Braz J Urol : Official Journal of the Brazilian Society of Urology
Antonio A OrnellasAline B de Santos Schwindt

Abstract

We evaluated the role of several prognostic factors in predicting death and/or progressive disease in patients with renal cell carcinoma. Between 2004 and 2010, 227 consecutive patients with renal cell carcinoma underwent radical nephrectomy at our Institute. All histological specimens were examined by the same pathologist. We considered certain histological parameters, including histological subtype, conventional Fuhrman grade, presence of sarcomatoid features, adrenal gland infiltration, invasion of the perinephric fat, vascular embolization, collecting system invasion, presence or absence of tumour necrosis (0 %, 1 % to 49 %, or 50 % or greater) and regional lymph node metastasis. Variables significantly associated with death and/or progressive disease on univariate analysis were histological subtype (p = 0.006), Fuhrman grade (p < 0.0001), tumor necrosis (p = 0.009), perinephric fat invasion (p = 0.002), vascular embolization (p = 0.0002), presence of lymph node involvement (p < 0.002), tumor size (p = 0.0006), TNM stage (p < 0.00001) and presence of metastasis (p < 0.00001). In the multivariable model histological subtype, tumor necrosis, lymph node involvement and presence of metastasis were independent risk factors for d...Continue Reading

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Citations

Oct 22, 2013·Environmental Science & Technology·Tara W HudiburgBeverly E Law
Aug 7, 2013·Journal of Agricultural and Food Chemistry·Patrícia A B RamosArmando J D Silvestre
Dec 11, 2013·Tissue Engineering. Part B, Reviews·Serge OstrovidovAli Khademhosseini
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Nov 2, 2012·International Journal of Urology : Official Journal of the Japanese Urological Association·Antonio Augusto Ornellas
May 18, 2006·World Journal of Surgical Oncology·Shailesh V ShrikhandeHelmut Friess
Oct 20, 2009·The Journal of Urology·Robert S SvatekCurtis A Pettaway
Jan 22, 2005·European Urology·F AlgabaUNKNOWN Uropathology Working Group
Sep 25, 2014·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Daniel D'Oliveira SilvaGustavo Franco Carvalhal
Mar 22, 2016·Oncology Letters·Wen Hui WengSee Tong Pang
Aug 3, 2017·Revista do Colégio Brasileiro de Cirurgiões·Marcus Vinicius Silva Araújo GurgelMarcos Venício Alves Lima

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